Skip to main content

Advertisement

SpringerLink
Log in

Visfatin and adiponectin as novel markers for evaluation of metabolic disturbance in recently diagnosed rheumatoid arthritis patients

  • Original Article
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

The aim is to assess metabolic disturbance in early rheumatoid arthritis patients and its relation to the clinical characteristics of patients. Forty recently diagnosed untreated rheumatoid arthritis (RA) patients with disease duration less than 1 year (group I) along with age- and sex-matched forty healthy volunteers who served as controls (group II) were studied. Disease activity score was used to assess disease activity. Blood pressure, BMI, glucose, insulin and complete lipid profile, visfatin, and adiponectin were measured. Insulin resistance (IR) was estimated by the homeostasis model assessment for insulin resistance (HOMA-IR). Beta-cell function was estimated by the homeostasis model assessment (HOMA-B). Also, rheumatoid factor, anticyclic citrullinated peptide antibodies were measured. Group I had significantly higher fasting insulin, HOMA-(IR, B), visfatin, lipid profile (except HDL), and lower adiponectin versus group II (p = 0.000). There were significant positive correlations between visfatin and the following biochemical parameters: insulin, HOMA-IR, HOMA-B, cholesterol, triglycerides, LDL-C (p = 0.05, 0.029, 0.005, 0.001, 0.002, 0.045, respectively). Also, the disease activity score was positively correlated with visfatin (p = 0.003). Meanwhile, there were significant negative correlations between adiponectin and the following biochemical parameters: insulin, HOMA-IR, HOMA-B, cholesterol, triglycerides, LDL-C, visfatin (p = 0.031, 0.023, 0.001, 0.000, 0.000, 0.016, 0.000, respectively). Also, the disease activity score was negatively correlated with adiponectin (p = 0.001). The findings of the present study showed that recently diagnosed untreated RA patients are characterized by a severe metabolic disturbance state that is driven primarily by disease activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dessein P, Joffe B, Singh S (2005) Biomarkers of endothelial dysfunction cardiovascular risk factors and atherosclerosis in rheumatoid arthritis. Arthritis Res Ther 7(3):634–643

    Article  Google Scholar 

  2. Dessein PH, Joffe BI (2006) Insulin resistance and impaired beta cell function in rheumatoid arthritis. Arthritis Rheum 54(9):2765–2775

    Article  PubMed  CAS  Google Scholar 

  3. Doran M (2007) Rheumatoid arthritis and diabetes mellitus: evidence for an association? J Rheumatol 34:460–462

    PubMed  Google Scholar 

  4. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC, Lenfant C (2004) Definition of metabolic syndrome report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on scientific issues related to definition. Circulation 109:433–438

    Article  PubMed  Google Scholar 

  5. Targońska-Stępniak B, Dryglewska M, Majdan M (2009) Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis. Rheumatol Int Clin Exp Investig. doi:10.1007/s00296-009-1053

    Google Scholar 

  6. Toussirot É, Streit G, Wendling D (2007) The contribution of adipose tissue and adipokines to inflammation in joint diseases. Curr Med Chem 14:1095–1100

    Article  PubMed  CAS  Google Scholar 

  7. Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, Matsuki Y, Murakami M, Ichisaka T, Murakami H et al (2005) Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 307:426–430

    Article  PubMed  CAS  Google Scholar 

  8. Chen MP, Chung FM, Chang DM, Tsai JC, Huang HF, Shin SJ, Lee YJ (2006) Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. J Clin Endocr Metab 91:295–299

    Google Scholar 

  9. Nishida K, Okada Y, Nawata M, Saito K, Tanaka Y (2008) Induction of hyperadiponectinemia following long-term treatment of patients with rheumatoid arthritis with infliximab (IFX), an anti-TNF-alpha antibody. Endocr J 55(1):213–216

    Article  PubMed  CAS  Google Scholar 

  10. Otero M, Lago R, Gomez R, Lago F, Dieguez C, Gomez-Reino JJ, Gualillo O (2006) Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis 65:1198–1201

    Article  PubMed  CAS  Google Scholar 

  11. Nagashima T, Okubo-Fornbacher H, Aoki Y, Kamata Y, Kimura H, Kamimura T, Nara H, Iwamoto M, Yoshio T, Okazaki H, Minota S (2008) Increase in plasma levels of adiponectin after administration of anti-tumor necrosis factor agents in patients with rheumatoid arthritis. J Rheumatol 35(5):936–938

    PubMed  CAS  Google Scholar 

  12. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS (1988) The American Rheumatism Association revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324

    Article  PubMed  CAS  Google Scholar 

  13. Prevoo ML, van’t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL (1995) Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38(1):44–48

    Article  PubMed  CAS  Google Scholar 

  14. Gallagher D, Visser M, Sepulveda D, Pierson R, Harris T, Heymsfield SB (1996) How useful is body mass index for comparison of body fatness across age, sex and ethnic groups? Am J Epidemiol 143:228–239

    Article  PubMed  CAS  Google Scholar 

  15. Friedwald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502

    Google Scholar 

  16. Nielen MM, van Schaardenburg D, Reesink HW et al (2004) Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 50:380–386

    Article  PubMed  Google Scholar 

  17. Bonora E, Formentini G, Calcaterra F, Lombardi S, Marini F, Zenari L, Saggiani F, Poli M, Perbellini S, Raffaelli A, Cacciatori V, Santi L, Targher G, Bonadonna R, Muggeo M (2002) HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the Verona Diabetes Complications Study. Diabetes Care 25:1135–1141

    Article  PubMed  Google Scholar 

  18. Maradit-Kremers H, Crowson CS, Nicola PJ, Ballman KV, Roger VL, Jacobsen SJ et al (2005) Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study. Arthritis Rheum 52:402–411

    Article  PubMed  Google Scholar 

  19. van Halm VP, Nielen MMJ, Nurmohamed MT, van Schaardenburg D, Reesink HW, Voskuyl AE et al (2007) Lipids and inflammation: serial measurements of the lipid profile of blood donors who later developed rheumatoid arthritis. Ann Rheum Dis 66:184–188

    Article  PubMed  Google Scholar 

  20. Rall LC, Roubenoff R (2004) Rheumatoid cachexia, metabolic abnormalities, mechanisms and interventions. Rheumatology 43:1219–1223

    Article  PubMed  CAS  Google Scholar 

  21. Cantaert T, De Rycke L, Bongartz T, Nichola AP, Matteson EL (2006) Citrullinated proteins in rheumatoid arthritis. Arthritis Rheum 60:1356–1400

    Google Scholar 

  22. Niewold TB, Harrison MJ, Paget SA (2007) Anti-CCP antibody testing as a diagnostic and prognostic tool in rheumatoid arthritis. QJM 100(4):193–201

    Article  PubMed  CAS  Google Scholar 

  23. Dessein PH, Stanwix AE, Joffe BI (2002) Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol as well as clustering of metabolic syndrome features in rheumatoid arthritis. Arthritis Res 4:R5

    Article  PubMed  Google Scholar 

  24. Sattar N, McCarey DW, Capell H, McInnes IB (2003) Explaining how “high grade” systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation 108:2957–2963

    Article  PubMed  Google Scholar 

  25. Escárcega RO, García-Carrasco M, Fuentes-Alexandro S, Jara LJ, Rojas-Rodriguez J, Escobar-Linares LE et al (2006) Insulin resistance, chronic inflammatory state and the link with systemic lupus erythematosus-related coronary disease. Autoimmun Rev 6:48–53

    Google Scholar 

  26. Önde ME, Top C, Öncül O (2008) The correlation of insulin resistance with serum tumor necrosis factor-alpha levels in patients with rheumatoid arthritis. Endocrinologist 18:178–181

    Article  Google Scholar 

  27. Shahin D, Eltoraby E, Mesbah A, Houssen M (2010) Insulin resistance in early untreated rheumatoid arthritis patients. Clin Biochem 43(7):661–665

    Article  PubMed  CAS  Google Scholar 

  28. Karlson EW, Chibnik LB, Tworoger SS, Lee IM, Buring JE, Shadick NA et al (2009) Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies. Arthritis Rheum 60:641–652

    Article  PubMed  CAS  Google Scholar 

  29. van Halm VP, Nielen MMJ, Nurmohamed MT, van Schaardenburg D, Reesink HW, Voskuyl E et al (2007) Lipids and inflammation: serial measurements of the lipid profile of blood donors who later developed rheumatoid arthritis. Ann Rheum Dis 66:184–188

    Article  PubMed  Google Scholar 

  30. Maradit-Kremers H, Crowson CS, Nicola PJ, Ballman KV, Roger VL, Jacobsen SJ et al (2005) Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study. Arthritis Rheum 52:402–411

    Article  PubMed  Google Scholar 

  31. Burger D, Dayer JM (2002) High-density lipoprotein-associated apolipoprotein A-1: the missing link between infection and chronic inflammation? Autoimmun Rev 1:111–117

    Article  PubMed  CAS  Google Scholar 

  32. Georgiadis AN, Papavasiliou EC, Lourida ES, Alamanos Y, Kostara C, Tselepis AD et al (2006) Atherogenic lipid profile is a feature characteristic of patients with early rheumatoid arthritis: effect of early treatment—a prospective, controlled study. Arthritis Res Ther 8:R 82

    Article  Google Scholar 

  33. Georgiadis AN, Voulgari PV, Argyropoulou MI, Alamanos Y, Elisaf M, Tselepis AD et al (2008) Early treatment reduces the cardiovascular risk factors in newly diagnosed rheumatoid arthritis patients. Semin Arthritis Rheum 38:13–19

    Article  PubMed  CAS  Google Scholar 

  34. Steiner G, Urowitz MB (2009) Lipid profiles in patients with rheumatoid arthritis: mechanisms and the impact of treatment. Semin Arthritis Rheum 38:372–381

    Article  PubMed  CAS  Google Scholar 

  35. Papa C, Netea MG, Radstake T, Van Der Meer JWM, Stalenhoef AFH (2005) Influence of anti-tumour necrosis factor therapy on cardiovascular risk factors in patients with active rheumatoid arthritis. Ann Rheum Dis 64:303–305

    Article  Google Scholar 

  36. La Montagna G, Cacciapuoti F, Buono R, Manzella D, Mennillo GA, Arciello A et al (2007) Insulin resistance is an independent risk factor for atherosclerosis in rheumatoid arthritis. Diabetes Vasc Dis Res 4:130–135

    Article  Google Scholar 

  37. Rasouli N, Kern PA (2008) Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 93:S64–S73

    Article  PubMed  CAS  Google Scholar 

  38. Jia SH, Li Y, Parodo J, Kapus A, Fan L, Rotstein OD, Marshall JC (2004) Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Investig 113:1318–1327

    PubMed  CAS  Google Scholar 

  39. Alkady EA, Ahmed HM, Tag L, Abdou MA (2011) Serum and synovial adiponectin, resistin, and visfatin levels in rheumatoid arthritis patients. Relation to disease activity. Z Rheumatol 70(7):602–608

    Article  PubMed  CAS  Google Scholar 

  40. Davutoglu M, Ozkaya M, Guler E, Garipardıc M, Gursoy H, Karabiber H, Kılınc M (2009) Plasma visfatin concentrations in childhood obesity: relationships to insulin resistance and anthropometric indices. Swiss Med Wkly 139(1–2):22–27

    PubMed  Google Scholar 

  41. Zakaria S, Farouk G, El Saadany H, Mahmoud Selim H (2010) Changes in visfatin, adiponectin, leptin and ghrelin levels in patients with rheumatoid arthritis and their correlation with disease activity. Turk J Biochem 35(1):50–57

    Google Scholar 

  42. Rho YH, Solus J, Sokka T, Oeser ABS, Chung CP, Gebretsadik T, Shintani A, Pincus T, Stein CM (2009) Adipocytokines Are Associated with Radiographic Joint Damage in Rheumatoid Arthritis. Arthritis Rheum 60(7):1906–1914

    Article  PubMed  CAS  Google Scholar 

  43. Fantuzzi G (2008) Adiponectin and inflammation: consensus and controversy. J Allergy Clin Immunol 121:326–330

    Article  PubMed  CAS  Google Scholar 

  44. Lewicki M, Kotyla P, Kucharz E (2008) Etanercept increases adiponectin level in woman with rheumatoid arthritis. Clin Rheumatol 27:1337–1338

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine, Minia University, El Minia, Egypt

    Sahar Hossam El-Hini

  2. Department of Rheumatology and Rehabilitation, Faculty of Medicine, Minia University, El Minia, Egypt

    Faten Ismail Mohamed, Amel Ali Hassan & Fatma Ali

  3. Department of Clinical Pathology, Faculty of Medicine, Minia University, El Minia, Egypt

    Amel Mahmoud

  4. Department of Physiology, Faculty of Medicine, Minia University, El Minia, Egypt

    Hanaa M. Ibraheem

Authors
  1. Sahar Hossam El-Hini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Faten Ismail Mohamed
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Amel Ali Hassan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fatma Ali
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Amel Mahmoud
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hanaa M. Ibraheem
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Faten Ismail Mohamed.

Rights and permissions

Reprints and permissions

About this article

Cite this article

El-Hini, S.H., Mohamed, F.I., Hassan, A.A. et al. Visfatin and adiponectin as novel markers for evaluation of metabolic disturbance in recently diagnosed rheumatoid arthritis patients. Rheumatol Int 33, 2283–2289 (2013). https://doi.org/10.1007/s00296-013-2714-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-013-2714-3

Keywords

Search

Navigation