Abstract
Hintergrund
Aktuelle Daten belegen den Einfluss der Adipozytokine Adiponectin, Visfatin und Resistin auf Entzündung, Immunantwort und Gewebezerstörung und weisen auf verschiedene Zusammenhänge zwischen diesen und einer Arthritis hin.
Ziel
Ziel dieser Studie war es, die Spiegel von Adiponectin, Visfatin und Resistin im Serum und in der Gelenkflüssigkeit bei Patienten mit rheumatoider Arthritis (RA) und ihren Bezug zur Krankheitsaktivität zu ermitteln.
Patienten und Methoden
In die Studie wurden 70 weibliche Patienten mit RA und 30 gesunde Kontrollen entsprechenden Alters und Geschlechts aufgenommen. Die Krankheitsaktivität bei den RA-Patienten wurde mit dem auf 28 Gelenke bezogenen Krankheitsaktivitätswert (Disease Activity Score, DAS28) ermittelt und die Patienten in 2 Untergruppen eingeteilt: 39 mit Krankheitsaktivität (Gruppe A) und 31 in Remission (Gruppe B). Gelenkflüssigkeit wurde durch Gelenkpunktion der betroffenen Kniegelenke von 39 Patienten mit aktiver Erkrankung gewonnen. Die Konzentrationen von Adiponectin, Visfatin und Resistin im Serum wurden bei RA-Patienten und Kontrollen bestimmt, ihre Konzentration in der Gelenkflüssigkeit dagegen nur bei der Gruppe mit aktiver RA – mittels spezifischer ELISA-Tests („enzyme-linked immunosorbent assay“).
Ergebnisse
Die Spiegel von Adiponectin und Visfatin im Serum waren bei sämtlichen RA-Patienten und denjenigen mit aktiver Erkrankung signifikant höher als bei der Kontrollgruppe und den Patienten in Remission. Der Resistinspiegel wies keinen signifikanten Unterschied zwischen Patienten und Kontrollen auf. Adiponectin und Visfatin im Serum und in der Gelenkflüssigkeit waren positiv mit dem DAS28-ESR-Wert bei RA-Patienten mit aktiver Erkrankung korreliert.
Fazit
Die vorliegenden Daten zeigen, dass Adiponectin und Visfatin mit der Krankheitsaktivität bei RA-Patienten verknüpft sind und an der Progression der RA beteiligt sein könnten.
Die englische Volltextversion dieses Beitrags ist über SpringerLink (unter „Supplemental“) verfügbar.
Abstract
Background
Recent data provided evidence on the implication of the adipocytokines adiponectin, visfatin, and resistin in inflammation, immune response, and tissue destruction and revealed several links between them and arthritis.
Aim of the study
The purpose of this study was to assess the levels of adiponectin, visfatin, and resistin in serum and synovial fluid of patients with rheumatoid arthritis (RA) and their relationship with disease activity.
Subjects and methods
A total of 70 female patients with RA and 30 age- and sex-matched healthy controls were enrolled. The clinical activity of RA patients was assessed according to the 28 joint count Disease Activity Score and patients were classified into two groups: 39 patients with active disease (group A) and 31 patients in remission (group B). Synovial fluid was obtained by arthrocentesis of the affected knee joints from 39 patients with active disease. Serum adiponectin, visfatin, and resistin concentrations were measured in RA patients and controls, while a specific enzyme-linked immunosorbent assay was used to measure the synovial concentrations of adiponectin, visfatin, and resistin in the group of patients with active RA.
Results
Serum levels of adiponectin and visfatin were significantly higher in all RA patients and patients with active disease compared to the control group and patients in remission. No significant difference was observed in the resistin level between patients and controls. Serum and synovial adiponectin and visfatin were positively correlated with DAS28-ESR in RA patients with active disease.
Conclusion
Our data demonstrated that adiponectin and visfatin are related to disease activity in RA patients and might be involved in the progression of RA.
The English full-text version of this article is available at SpringerLink (under “Supplemental”).
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Alkady, E., Ahmed, H., Tag, L. et al. Adiponectin, Resistin und Visfatin in Serum und Gelenkflüssigkeit bei Patienten mit rheumatoider Arthritis. Z. Rheumatol. 70, 602–608 (2011). https://doi.org/10.1007/s00393-011-0834-2
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DOI: https://doi.org/10.1007/s00393-011-0834-2