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Pathophysiology and antioxidant status of patients with fibromyalgia

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Abstract

Fibromyalgia syndrome (FMS) is characterized by systemic pain of unknown etiology and is often accompanied by various psychological symptoms. Research on different parameters in fibromyalgia (FM) indicates that multifactors are involved in its pathophysiology; such as genetic factors, substance P, serotonin, hypothalamic pituitary adrenal axis (HPA), muscles metabolic dysfunction, reactive oxygen species (ROS) and reactive nitrogen species (RNS). Oxidative stress has also been implicated in the pathophysiology of FM; therefore, supplementation with antioxidants may be important in modulation of the effects of ROS in patients with FM.

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Acknowledgments

This study was financially supported by a grant from Higher Education Commission (H. E. C.), Islamabad, Pakistan.

Conflict of interest statement

The authors do not have any financial conflict.

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Authors and Affiliations

  1. Zoology Department, G. C. University, Lahore, 54000, Pakistan

    Riffat Iqbal & M. S. Mughal

  2. Zoology Department, Punjab University, New Campus, Lahore, Pakistan

    Najma Arshad

  3. NUST Centre of Virology and Immunology (NCVI), National University of Sciences and Technology (NUST), Tameez ud din road, Rawalpindi, Pakistan

    Muhammad Arshad

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  1. Riffat Iqbal
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  2. M. S. Mughal
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  3. Najma Arshad
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  4. Muhammad Arshad
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Correspondence to Muhammad Arshad.

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Iqbal, R., Mughal, M.S., Arshad, N. et al. Pathophysiology and antioxidant status of patients with fibromyalgia. Rheumatol Int 31, 149–152 (2011). https://doi.org/10.1007/s00296-010-1470-x

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  • DOI: https://doi.org/10.1007/s00296-010-1470-x

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