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A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population

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Abstract

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance. Recently, single-nucleotide polymorphisms (SNPs) in tumor necrosis factor (TNF) superfamily gene TNFSF4 have been shown to be associated with SLE in European and Hong Kong Chinese populations. But it is unknown whether it is also associated with the disease in Mainland Chinese Han population. We genotyped the SNPs rs1234315 near the TNFSF4 gene in 1,344 SLE patients and 4,315 controls of Chinese Han population and confirmed the association between the SNP and the SLE [odds ratios (ORs) of 1.45 and P values of 1.5 × 10−16]. The stratification analyses showed that rs1234315 was more strongly associated with SLE patients with arthritis. Our study not only suggested that the TNFSF4 gene was associated with SLE in Chinese Han population, but also implied that it might be a common genetic factor predisposing to the development of SLE in multiple populations.

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Acknowledgments

We thank all the participants of this study, which was supported by the Key Project of National Natural Science Foundation (nos 30530670 and 30830089).

Conflict of interest statement

The authors declared no competing financial interests.

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Authors and Affiliations

  1. Department of Dermatology, Institute of Dermatology, No. 1 Hospital, Anhui Medical University, 69 Meishan Road, 230032, Hefei, Anhui, China

    Sheng-Quan Zhang, Jian-Wen Han, Liang-Dan Sun, Wen-sheng Lu, Xian-Yong Yin, Xue-Jun Zhang & Sen Yang

  2. Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China

    Sheng-Quan Zhang, Jian-Wen Han, Liang-Dan Sun, Wen-sheng Lu, Xian-Yong Yin, Xue-Jun Zhang & Sen Yang

  3. Department of Dermatology and Venereology, Anhui Medical University, 230032, Hefei, Anhui, China

    Sheng-Quan Zhang, Jian-Wen Han, Liang-Dan Sun, Wen-sheng Lu, Xian-Yong Yin, Xue-Jun Zhang & Sen Yang

  4. Department of Biochemistry and Molecular Biology, Anhui Medical University, 230032, Hefei, Anhui, China

    Sheng-Quan Zhang

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  1. Sheng-Quan Zhang
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  2. Jian-Wen Han
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  7. Sen Yang
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Correspondence to Sen Yang.

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Zhang, SQ., Han, JW., Sun, LD. et al. A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population. Rheumatol Int 31, 227–231 (2011). https://doi.org/10.1007/s00296-009-1247-2

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  • DOI: https://doi.org/10.1007/s00296-009-1247-2

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