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Genetic influence of DNAM-1 (DNAX accessory molecule-1) gene polymorphism (rs 763361) on susceptibility and disease activity of systemic lupus erythematosus and rheumatoid arthritis in Egyptian patients

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Abstract

Genome-wide association studies have led to the involvement of multiple susceptibility genes in the development of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). The present case control study was conducted to determine the possible association of DNAM-1(C/T, rs 763361) single nucleotide polymorphism (SNP) with RA and SLE in the Egyptian population. This study aimed to determine the possible genetic influence of SNP on disease activity in SLE (represented by SLEDAI score) and in RA patients (represented by DAS28). Fifty SLE patients compared to 43 healthy controls and 35 RA patients compared to 30 healthy controls were included in the study. The PCR-RFLP technique was used to detect DNAM-1(C/T rs 763361) gene polymorphism. Analysis of the frequency distribution of both allele and genotype frequency distribution of SLE and RA patients compared to healthy control subjects did not reveal a significant association between SLE and RA patients and the rs763361. Analysis of the disease activity status in lupus nephritis (LN) and non-lupus nephritis patients revealed a significant association between DNAM-1(C/T) SNP and LN patients carrying the TT and CT genotypes (P = 0.009 and 0.004; respectively). DNAM-1(C/T rs763361) SNP is not associated with the development of SLE and RA in Egyptian population. The SNP might be associated with disease activity status represented by SLEDAI score in LN patients carrying CC and CT genotypes, respectively.

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Acknowledgements

We would like to express our deepest gratitude to all participants in the study; without them, this work would not have been accomplished.

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Authors and Affiliations

  1. Immunology unit, Clinical and Chemical Pathology Department, Beni-suef Faculty of Medicine, Beni-suef University, Beni-suef, 62511, Egypt

    Rabab A. Mohamed

  2. Rheumatology and Rehabilitation Department, Beni-suef Faculty of Medicine, Beni-suef University, Beni-suef, 62511, Egypt

    Mervat I. Abd Elazeem

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  1. Rabab A. Mohamed
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  2. Mervat I. Abd Elazeem
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Correspondence to Rabab A. Mohamed.

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Ethical approval

The present case–control study was conducted in BENI-SUEF UNIVERSITY HOSPITAL. All SLE and RA patients and control subjects were informed of the purpose of the study, and their consent was obtained, and the study was approved by the local ethics committee. All procedures performed in the studies involving human participants were in accordance institutional ethical standards and with the 1964 Helsinki Declaration and its later amendments in 2004.

Funding

This work was not funded by any organization. The authors contributed equally in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.

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The authors declare that they have no conflict of interest.

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The manuscript has not been published elsewhere and has not been submitted simultaneously for publication elsewhere.

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Mohamed, R.A., Abd Elazeem, M.I. Genetic influence of DNAM-1 (DNAX accessory molecule-1) gene polymorphism (rs 763361) on susceptibility and disease activity of systemic lupus erythematosus and rheumatoid arthritis in Egyptian patients. Comp Clin Pathol 26, 543–552 (2017). https://doi.org/10.1007/s00580-017-2406-6

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  • DOI: https://doi.org/10.1007/s00580-017-2406-6

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