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Bone mineral density in patients with familial Mediterranean fever

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Abstract

This study was carried out to determine lumbar and femoral bone mineral density (BMD) in patients with familial Mediterranean fever (FMF), an autosomal-recessive disease characterized by recurrent episodes of peritonitis, pleuritis, and arthritis, which are usually associated with fever. In patients with FMF and control subjects, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured. BMD was determined at the lumbar spine (L1–4) and the femoral regions (neck and total) using dual energy X-ray absorptiometry. Twenty-eight FMF patients and 30 control subjects without a history of inflammatory disease participated in our study. The demographic variables, such as age, sex and body mass index were similar between patients and controls (P > 0.05). We found statistically significant difference in ESR and CRP between FMF patients and controls (P < 0.01, P < 0.05 respectively). There was statistically significant difference in lumbar spine, femoral neck, and total femur BMD between FMF patients and control groups (P < 0.001, P < 0.01, P < 0.01 respectively).Our study indicates that lumbar spine and femoral neck and total femur BMD in patients with FMF may be lower than in healthy subjects.

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Medical Faculty, Ataturk University, Erzurum, Turkey

    Kadir Yildirim, Saliha Karatay, Hulya Uzkeser & Akın Erdal

  2. Department of Nephrology, Medical Faculty, Ataturk University, Erzurum, Turkey

    Ramazan Cetinkaya

  3. Department of Endocrinology, Medical Faculty, Ataturk University, Erzurum, Turkey

    Ilyas Capoglu

  4. Department of Physical Medicine and Rehabilitation, Bolge Training and Research Hospital, Erzurum, Turkey

    Fazile Hatipoglu Erdem

  5. Atatürk Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, 25240, Erzurum, Turkey

    Kadir Yildirim

Authors
  1. Kadir Yildirim
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  2. Saliha Karatay
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  3. Ramazan Cetinkaya
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  4. Hulya Uzkeser
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  5. Akın Erdal
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  6. Ilyas Capoglu
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  7. Fazile Hatipoglu Erdem
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Correspondence to Kadir Yildirim.

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Yildirim, K., Karatay, S., Cetinkaya, R. et al. Bone mineral density in patients with familial Mediterranean fever. Rheumatol Int 30, 305–308 (2010). https://doi.org/10.1007/s00296-009-0950-3

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  • DOI: https://doi.org/10.1007/s00296-009-0950-3

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