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Inflammatory response in patients with active and inactive osteoarthritis

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Abstract

In the present study, we have investigated comparatively the inflammatory response of patients with active and inactive osteoarthritis. The sera from 31 healthy individuals, 37 patients with active OA, and 19 patients with inactive OA were assayed for TNF-α, IL-6, sRANKL, RANTES, and MRP8 using ELISA in order to evaluate their potential as markers of disease activity. Also, the spontaneous and LSP-induced release of TNF-α and IL-6 by peripheral blood neutrophils was determined. The activation of OA is associated with elevated TNF-α, IL-6, and RANTES serum levels while sRANKL and MRP8 appeared to be increased in both active and inactive OA. The neutrophil spontaneous and up-regulated by LPS cytokine release can contribute to the exacerbation of OA.

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Acknowledgments

This work was supported by a Grant KT-X-1707 from the National Science Fund, Ministry of Education and Science, Bulgaria.

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Authors and Affiliations

  1. Clinic of Internal Diseases, National Transport Hospital, Sofia, Bulgaria

    Antoaneta Toncheva

  2. Department of Immunology, Institute of Microbiology, 1113, Sofia, Bulgaria

    Mimi Remichkova, Petya Dimitrova & Nina Ivanovska

  3. Department of Clinical Immunology, National Transport Hospital, Sofia, Bulgaria

    Krassimira Ikonomova

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  1. Antoaneta Toncheva
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  2. Mimi Remichkova
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  3. Krassimira Ikonomova
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  5. Nina Ivanovska
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Correspondence to Nina Ivanovska.

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Toncheva, A., Remichkova, M., Ikonomova, K. et al. Inflammatory response in patients with active and inactive osteoarthritis. Rheumatol Int 29, 1197–1203 (2009). https://doi.org/10.1007/s00296-009-0864-0

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  • DOI: https://doi.org/10.1007/s00296-009-0864-0

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