Abstract
There are controversial reports that TNF-a promoter polymorphism may be an independent marker of susceptibility to rheumatoid arthritis (RA). We used Polymerase chain reaction amplification and Restriction fragment length polymorphism for analysis of the polymorphism at position -308 in promoter of TNF-α gene in 34 patients with RA and 30 healthy individuals. Distribution of TNF-genotypes in RA patients did not differ from that in controls. Moreover, there was apparent association between the -308 TNF-α polymorphism and erosions in hand x-Ray was found (P value = 0.043). We suggest that TNF-α -308 promoter polymorphism is not a genetic risk factor for RA susceptibility but may be associated with radiographic damage in rheumatoid patients.
Similar content being viewed by others
References
Brinkman BM, Huizinga TW, Kurban SS, van der Velde EA, Schreuder GM, Hazes JM, et al (1997) Tumour necrosis factor alpha gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease? Br J Rheumatol 36:516–521
Feldmann M, Brennan FM, Maini RN (1996) Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14:397–440
Rodriguez-Carreon AA, Zuniga J, Hernandez-Pacheco G, Rodriguez-Perez JM, Balog A, Klausz G, et al (2004) Investigation of the prognostic value of TNF-alpha gene polymorphism among patients treated with infliximab, and the effects of infliximab therapy on TNF-alpha production and apoptosis. Pathobiology 71:274–280
Aguillon JC, Cruzat A, Aravena O, Salazar L, Llanos C, Cuchacovich M. (2006) Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution? Immunobiology 211:78–84
Pawlik A, Florczak M, Ostanek L, Brzosko M, Brzosko I, Szklarz BG (2005) TNF-alpha−308 promoter polymorphism in patients with rheumatoid arthritis. Scand J Rheumatol 34:22–26
Barton A, Platt H, Salway F, Symmons D, Barrett E, Bukhari M, et al (2004) Polymorphisms in the tumour necrosis factor gene are not associated with severity of inflammatory polyarthritis. Ann Rheum Dis 63:280–284
Wilson AG, de Vries N, van de Putte LB, Duff GW (1995) A tumour necrosis factor alpha polymorphism is not associated with rheumatoid arthritis. Ann Rheum Dis 54:601–603
Lacki JK, Moser R, Korczowska I, Mackiewicz S, Muller W (2000) TNF-alpha gene polymorphism does not affect the clinical and radiological outcome of rheumatoid arthritis. Rheumatol Int 19:137–140
Vinasco J, Beraun Y, Nieto A, Fraile A, Mataran L, Pareja E et al (1997) Polymorphism at the TNF loci in rheumatoid arthritis. Tissue Antigens 49:74–78
Danis VA, Millington M, Hyland V, Lawford R, Huang Q, Grennan D (1995) Increased frequency of the uncommon allele of tumour necrosis factor alpha gene polymorphism in rheumatoid arthritis and systemic lupus erythematosus. Dis Markers 12:127–133
Bayley JP, Ottenhoff TH, Verweij CL (2004) Is there a future for TNF promoter polymorphisms? Genes Immun 5:315–329
Author information
Authors and Affiliations
Corresponding author
Additional information
All work was funded by the Chancellor for Research of Mashhad University of Medical Science.
Rights and permissions
About this article
Cite this article
Rezaieyazdi, Z., Afshari, J.T., Sandooghi, M. et al. Tumour necrosis factor a −308 promoter polymorphism in patients with rheumatoid arthritis. Rheumatol Int 28, 189–191 (2007). https://doi.org/10.1007/s00296-007-0444-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-007-0444-0