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Nucleo-cytoplasmic partitioning of proteins in plants: implications for the regulation of environmental and developmental signalling

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Abstract

Considerable progress has been made in the past few years in characterising Arabidopsis nuclear transport receptors and in elucidating plant signal transduction pathways that employ nucleo-cytoplasmic partitioning of a member of the signal transduction chain. This review briefly introduces the major principles of nuclear transport of macromolecules across the nuclear envelope and the proteins involved, as they have been described in vertebrates and yeast. Proteins of the plant nuclear transport machinery that have been identified to date are discussed, the focus being on Importin β-like nuclear transport receptors. Finally, the importance of nucleo-cytoplasmic partitioning as a regulatory tool for signalling is highlighted, and different plant signal transduction pathways that make use of this regulatory potential are presented.

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Acknowledgements

I thank Dorothea Haasen, Petra Hohenberger, Katja Schmied and Miriam Dewald for critical reading of the manuscript and helpful discussions; and thank all members of my group, former and present, for their enthusiasm. I thank R. Scott Poethig and Xuemei Chen for providing manuscripts ahead of publication. I apologise to colleagues whose work could not be covered. Financial support by grants from the Deutsche Forschungsgemeinschaft (SFB 388, ME 1116/3-1, 3-3, AFGN-ME1116/4-1) to T.M. is gratefully acknowledged.

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    Thomas Merkle

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Merkle, T. Nucleo-cytoplasmic partitioning of proteins in plants: implications for the regulation of environmental and developmental signalling. Curr Genet 44, 231–260 (2003). https://doi.org/10.1007/s00294-003-0444-x

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