Abstract
A random branched poly(hydroxyetheramine) was synthesized by ring-opening reaction of tetraethylenepentamine (TEPA) to ethylenediglycidol (EG), which was denoted as PTEG. PTEG has not only high charge density but also discrete charge distribution due to the introduction of hydrophilic hydroxyoligoether. In addition, PTEG contains all grades of protonable amines. Acid base titration indicated that PTEG was protonated in wide pH range from 5.0 to 11.0, which showed that PTEG had proton sponge effect as polyethylenimine and protonation ability at human physiological pH condition. In dilute aqueous solution, PTEG was complexed with weak anionic polymer, poly(acrylic acid) (PAA), into nanoparticles.
Similar content being viewed by others
References
Kim B, Peppas NA (2003) Polymer 44:3701
Tomić SL, Filipović JM (2004) Polym Bull 52:355
Lau C, Mi YL (2002) Polymer 43:823
Smith B, Sridhar S, Khan AA (2005) Eur Polym J 41:1859
Chaterjee SK, Nigam S, Kapoor V (1995) Polym Bull 35:489
Zhang YH, Binner J (2005) Polymer 46:10517
Rusu-Balaita L, DesbriSres J, Rinaudo M (2003) Polym Bull 50:91
Kwon HJ, Shikinaka K, Kakugo A, Gong JP, Osada Y (2007) Polym Bull 58:43
Wu CB, Hao JY, Deng XM, Liu Y (2007) J Appl Polym Sci 105:1533
Arguelles-Monal W, Cabrera G, Peniche C, Rinaudo M (2000) Polymer 41:2373
Bernabé P, Peniche C, Argüelles-Monal W (2005) Polym Bull 55:367
Wang XH, Du YM, Fan LH, Liu H, Hu Y (2005) Polym Bull 55:105
Xue WH, Diao HJ, Chen X, Wang CM, Chen JN, Zhang JF (2007) Eur J Pharm Biopharm 66:327
Yu HJ, Chen XS, Lu TC, Sun J, Tian HY, Hu J, Wang Y, Zhang PB, Jing XB (2007) Biomacromolecules 8:1425
Kim TH, Jiang HL, Jere D, Park IK, Cho MH, Nah JW, Choi YJ, Akaike T, Cho CS (2007) Prog Polym Sci 32:726
Jun YJ, Kim JH, Choi SJ, Lee HJ, Jun MJ, Sohn YS (2007) Bioorg Med Chem Lett 17:2975
Vroman B, Mazza M, Fernandez MR, Jerome R, Preat V (2007) J Control Release 118:136
Wang YX, Chen P, Shen JC (2006) Biomaterials 27:5292
Elfinger M, Maucksch C, Rudolph C (2007) Biomaterials 28:3448
Li SF, Dong W, Zong YW, Yin W, Jin GH, Hu QG, Huang XF, Jiang WH, Hua ZC (2007) Mol Ther 15:515
Zeng JM, Wang X, Wang S (2007) Biomaterials 28:1443
Rudolph C, Sieverling N, Schillinger U, Lesina E, Plank C, Thunemann AF, Schonberger H, Rosenecker J (2007) Biomaterials 28:1900
Park MR, Han KO, Han IK, Cho MH, Nah JW, Choi YJ, Cho CS (2005) J Control Release 105:367
Bettinger EP, Belguise-Valladier T, Zou P, Coll SM, Behr JL, Remy JP (1999) J Gene Med 1:210
Qiu LY, Bae YH (2007) Biomaterials 28:4132
Yang CA, Li HZ, Goh SH, Li J (2007) Biomaterials 28:3245
Li J, Yang C, Li HZ, Wang X, Goh SH, Ding JL, Wang DY, Leong KW (2006) Adv Mater 18:2969
Gabrielson NP, Pack DW (2006) Biomacromolecules 7:2427
Kim TH, Jiang HL, Jere D, Park IK, Cho MH, Nah JW, Choi YJ, Akaike T, Cho CS (2007) Prog Polym Sci 32:726
Wu CB, Hao JY, Deng XM (2007) Polymer 48:6272
Wu CB, Hao JY, Deng XM (2007) e-Polymers No.152:1
Plank C, Oberhauser B, Mechtler K, Koch C, Wagner E (1994) J Biol Chem 269:12918
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wu, Cb., Hao, Jy., Deng, Xm. et al. Random branched poly(hydroxyetheramine): a novel polycation with proton sponge effect and high density of discrete charge . Polym. Bull. 60, 635–645 (2008). https://doi.org/10.1007/s00289-008-0893-y
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00289-008-0893-y