Abstract
This paper concerns multiphase models of tumor growth in interaction with a surrounding tissue, taking into account also the interplay with diffusible nutrients feeding the cells. Models specialize in nonlinear systems of possibly degenerate parabolic equations, which include phenomenological terms related to specific cell functions. The paper discusses general modeling guidelines for such terms, as well as for initial and boundary conditions, aiming at both biological consistency and mathematical robustness of the resulting problems. Particularly, it addresses some qualitative properties such as a priori non-negativity, boundedness, and uniqueness of the solutions. Existence of the solutions is studied in the one-dimensional time-independent case.
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During the preparation of this work, the author was funded by a post-doctoral research scholarship “Compagnia di San Paolo” awarded by the National Institute for Advanced Mathematics “F. Severi” (INdAM, Italy).
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Tosin, A. Initial/boundary-value problems of tumor growth within a host tissue. J. Math. Biol. 66, 163–202 (2013). https://doi.org/10.1007/s00285-012-0505-1
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DOI: https://doi.org/10.1007/s00285-012-0505-1