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Lactobacillus acidophilus Autolysins Inhibit Helicobacter pylori In Vitro

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Abstract

Antibacterial activity of 17 strains of lactobacilli was tested against 10 strains of H. pylori. The inhibition observed was related to the acid production and the low pH attained. No relationship between CagA phenotype of H. pylori strains and tolerance to lactic acid was observed. In mixed cultures, L. acidophilus CRL 639 showed an autolytic behavior after 24 h of culture. At this moment, H. pylori CCUG17874 showed a decrease of 2 log-cycle, and no viable count was detected after 48 h. The bactericidal effect of L. acidophilus CRL 639 in mixed cultures is related to a proteinaceous compound released after cell lysis.

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Authors and Affiliations

  1. Centro de Referencia para Lactobacilos (CERELA), Chacabuco 145, 4000 Tucumán, Argentina, , , , , , AR

    Graciela L. Lorca & Graciela Font de Valdez

  2. Department of Medical Microbiology and Infectious Diseases, University of Lund, Sölvegatan 23, S-223 62 Lund, Sweden, , , , , , SE

    Torkel Wadström & Åsa Ljungh

Authors
  1. Graciela L. Lorca
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  2. Torkel Wadström
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  3. Graciela Font de Valdez
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  4. Åsa Ljungh
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Received: 19 June 2000 / Accepted: 12 July 2000

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Lorca, G., Wadström, T., Font de Valdez, G. et al. Lactobacillus acidophilus Autolysins Inhibit Helicobacter pylori In Vitro. Curr Microbiol 42, 39–44 (2001). https://doi.org/10.1007/s002840010175

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  • DOI: https://doi.org/10.1007/s002840010175

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