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Role of Nox2 in elimination of microorganisms

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Abstract

NADPH oxidase of the phagocytic cells (Nox2) transfers electrons from cytosolic NADPH to molecular oxygen in the extracellular or intraphagosomal space. The produced superoxide anion (O2 ·−) provides the source for formation of all toxic oxygen derivatives, but continuous O2 ·− generation depends on adequate charge compensation. The vital role of Nox2 in efficient elimination of microorganisms is clearly indicated by human pathology as insufficient activity of the enzyme results in severe, recurrent bacterial infections, the typical symptoms of chronic granulomatous disease. The goals of this contribution are to provide critical review of the Nox2-dependent cellular processes that potentially contribute to bacterial killing and degradation and to indicate possible targets of pharmacological interventions.

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Acknowledgements

The authors are indebted to Professor Thomas E. DeCoursey for valueable suggestions and critical reading of the manuscript. Experimental work carried out in the laboratory of L.E. has been supported by the Hungarian Research Fund (grants no. 62221 and 49851) and from the Hungarian Ministry of Health (grant no. 181/2006).

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  1. Laboratory of Host Defenses, Molecular Defenses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA

    Balázs Rada

  2. Department of Physiology, Semmelweis University, 1088, Puskin u. 9., Budapest, Hungary

    Csilla Hably, András Meczner, Csaba Timár, Gergely Lakatos, Péter Enyedi & Erzsébet Ligeti

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  1. Balázs Rada
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Rada, B., Hably, C., Meczner, A. et al. Role of Nox2 in elimination of microorganisms. Semin Immunopathol 30, 237–253 (2008). https://doi.org/10.1007/s00281-008-0126-3

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