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Apoptotic cell death and lupus

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Abstract

Programmed cell death and the disposal of cell corpses by phagocytic cells are highly regulated ongoing processes essential for the survival and well-being of higher organisms. Abnormalities in the susceptibility of certain cells to receptor-induced death are known to lead to certain human diseases (e.g., autoimmune lymphoproliferative syndrome) and may contribute to the pathogenesis of systemic lupus erythematosus. Impaired clearance of apoptotic cells is also likely to be an important factor in lupus pathogenesis, though the biological basis of such a defect remains elusive. Finally, the process of apoptosis has been shown to contribute to lupus disease effector mechanisms. A better understanding of the role of apoptosis in lupus very likely will lead to improved diagnosis and therapy.

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Acknowledgements

The author thanks Dr. Roberto Caricchio for his suggestions and critical review of the manuscript. This study was supported by grants from the US Dept. of Veterans Affairs, the US Public Health Service, and The Alliance for Lupus Research (New York, NY).

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  1. University of Pennsylvania, 421 Curie Boulevard, Suite 757, Philadelphia, PA, 19104, USA

    Philip L. Cohen

  2. Philadelphia VA Medical Center, University and Woodland Avenues, Philadelphia, PA, 19104, USA

    Philip L. Cohen

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Cohen, P.L. Apoptotic cell death and lupus. Springer Semin Immun 28, 145–152 (2006). https://doi.org/10.1007/s00281-006-0038-z

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