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Induction of antigen cross-presentation by Toll-like receptors

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Abstract

Cross-presentation is the pathway by which exogenous antigens are routed for presentation on MHC class I for activation of CD8+ T cells. This pathway is important for the development of CD8+ cytotoxic T lymphocyte responses against tumors and infectious pathogens that do not directly infect APC. We review studies showing that certain Toll-like receptors mediate cross-presentation by dendritic cells, initiating cytosolic processing of antigen after inducing dendritic cell maturation. The implications of these studies for understanding CD8+ T cell activation and implementing novel vaccine strategies is considered.

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Acknowledgments

This work was supported by NIH grants AI52406 (S.K.D.), AI40682 (E.R), AI-58743 (E.R.), and a grant from Dynavax Technologies (E.R.).

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  1. University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093–0663, USA

    Sandip K. Datta & Eyal Raz

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  1. Sandip K. Datta
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  2. Eyal Raz
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Correspondence to Sandip K. Datta.

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Datta, S.K., Raz, E. Induction of antigen cross-presentation by Toll-like receptors. Springer Semin Immun 26, 247–255 (2005). https://doi.org/10.1007/s00281-004-0174-2

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  • DOI: https://doi.org/10.1007/s00281-004-0174-2

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