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Overexpression of ANLN contributed to poor prognosis of anthracycline-based chemotherapy in breast cancer patients

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Abstract

Purpose

To investigate the associations of ANLN expression with prognosis of breast cancer and clinical outcome of anthracycline-based chemotherapy.

Methods

This study enrolled 308 breast cancer patients in which 264 of them received anthracycline-based chemotherapy. Immunohistochemistry was used to detect ANLN expression level of the patients. Clinical characteristics of the patients were collected, and associations of ANLN expression with prognosis were analyzed.

Results

Our results showed that ANLN expression was associated with survival of breast cancer patients, and it was also related to clinical outcome of patients received anthracycline-based chemotherapy. Breast cancer patients with high expression of ANLN would have poor prognosis and poor clinical outcome to anthracycline-based chemotherapy.

Conclusion

ANLN could be an independent prognosis predictor for breast cancer, and its expression might be used to predict the anthracycline-based chemotherapy clinical outcome in breast cancer patients.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (81572612) and the Fundamental Research Funds for the Central Universities of Central South University (2015zzts116).

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Authors and Affiliations

  1. Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China

    Zhan Wang, Mei-Zuo Zhong, Wu-Zhong Jiang & Wei-Bing Zhou

  2. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China

    Juan Chen & Zhao-Qian Liu

  3. Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha, 410078, People’s Republic of China

    Juan Chen & Zhao-Qian Liu

  4. Hunan Province Clinic Meditech Research Center for Breast Cancer, Changsha, 410008, People’s Republic of China

    Juan Huang & Yuan-Ping Hu

  5. Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China

    De-Yun Feng

  6. Department of Pathology, The third Xiangya Hospital, Central South University, Changsha, 410013, People’s Republic of China

    Zhi-Jiao Zhou

  7. Department of Pain, The third Xiangya Hospital, Central South University, Changsha, 410013, People’s Republic of China

    Xiao Luo

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  1. Zhan Wang
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Correspondence to Wu-Zhong Jiang or Wei-Bing Zhou.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Wang, Z., Chen, J., Zhong, MZ. et al. Overexpression of ANLN contributed to poor prognosis of anthracycline-based chemotherapy in breast cancer patients. Cancer Chemother Pharmacol 79, 535–543 (2017). https://doi.org/10.1007/s00280-017-3248-2

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  • DOI: https://doi.org/10.1007/s00280-017-3248-2

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