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Granular acute lymphoblastic leukemia with hypereosinophilic syndrome

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/l), features of hypereosinophilic syndrome, and acute lymphoblastic leukemia (ALL-L2), the latter characterized by the presence of granular blasts. Blasts were negative for myeloperoxidase, non-specific esterase, acid phosphatase, periodic-acid Schiff stain, and toluidine blue. They exhibited an early pre-B immunophenotype (TdT, CD19, CD10, CD20 and CD22 positive) and stained negative for T (CD7, CD2, CD5 and CD3) and myeloid markers (MPO, CD33 and CD13). Chromosomal analysis revealed a normal karyotype. To the best of our knowledge, this case represents the first report of the coexistence of granular ALL and hypereosinophilic syndrome.

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Authors and Affiliations

  1. Unit of Laboratory Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi 110029, India, , , , , , IN

    P. Jain, R. Kumar, S. Gujral & M. Anand

  2. Department of Paediatrics, All India Institute of Medical Sciences, New Delhi, India, , , , , , IN

    A. Kumar, A. Singh, Y. Jain, S. Dubey & L. S. Arya

Authors
  1. P. Jain
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  2. R. Kumar
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  3. S. Gujral
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  4. A. Kumar
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  5. A. Singh
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  6. Y. Jain
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  7. S. Dubey
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  8. M. Anand
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  9. L. S. Arya
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Received: 11 May 1999 / Accepted: 20 October 1999

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Jain, P., Kumar, R., Gujral, S. et al. Granular acute lymphoblastic leukemia with hypereosinophilic syndrome. Ann Hematol 79, 272–274 (2000). https://doi.org/10.1007/s002770050592

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  • DOI: https://doi.org/10.1007/s002770050592

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