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Antimicrobial therapy of febrile complications after high-dose chemotherapy and autologous hematopoietic stem cell transplantation—guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)

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Abstract

More than 18,000 autolgous transplantation were performed in Europe in the year 2009. It as a routine procedure in experienced centres. Even if there is a low mortality rate, infections are a major issue after transplantation, occurring in more than 60 % of the patients. In this review we discuss all aspects of infections after autologous stem transplantation, including epidemiology, diagnostics, therapeutic algorithms, prophylaxis and supportive therapy.

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Authors and Affiliations

  1. Klinik für Innere Medizin, Hämatologie/Onkologie und Palliativmedizin, Evangelisches Krankenhaus Bielefeld, Schildescher Str. 99, 33611, Bielefeld, Germany

    Florian Weissinger

  2. Department of Haematology, Imperial College at Hammersmith Hospital, London, UK

    Holger W. Auner

  3. Abteilung Innere Medizin I, Universitätsklinikum Freiburg, Freiburg im Breisgau, Germany

    Hartmut Bertz

  4. Klinik für Innere Medizin III, Universitätsklinikum Mannheim, Mannheim, Germany

    Dieter Buchheidt

  5. Klinik I für Innere Medizin und Zentrum für Klinische Studien, Universität zu Köln, Cologne, Germany

    Oliver A. Cornely

  6. Medizinische Klinik V, Universitätsklinikum Heidelberg, Heidelberg, Germany

    Gerlinde Egerer

  7. Medizinische Klinik und Poliklinik II, Julius-Maximilian-Universität Würzburg, Oberdürrbacher Straße 6, 97080, Würzburg, Germany

    Werner Heinz

  8. Klinik für Hämatologie und Onkologie, Klinikum Neuperlach, Munich, Germany

    Meinolf Karthaus

  9. Medizinische Klinik I, Klinikum Frankfurt (Oder), Frankfurt (Oder), Germany

    Michael Kiehl

  10. Klinik und Poliklinik für Innere Medizin C, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany

    William Krüger

  11. Abt. Onkologie und Hämatologie, Charité Universitätsmedizin-Campus Charité Mitte, Berlin, Germany

    Olaf Penack

  12. Medizinische Klinik 4, Klinikum Leverkusen, Leverkusen, Germany

    Stefan Reuter

  13. Medizinische Klinik und Poliklinik II, Charité Universitätsmedizin-Campus Charité Mitte, Berlin, Germany

    Markus Ruhnke

  14. Schwerpunktpraxis für Hämatologie und Onkologie, Weilheim, Germany

    Michael Sandherr

  15. 2. Medizinische Abteilung, Asklepios Klinik Altona, Hamburg, Germany

    Hans-Jürgen Salwender

  16. 3. Medizinische Abteilung, Johannes-Gutenberg-Universität Mainz, Mainz, Germany

    Andrew J. Ullmann

  17. Klinik I für Innere Medizin, Universität zu Köln, Cologne, Germany

    Dirk T. Waldschmidt

  18. Innere Medizin IV, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany

    Hans H. Wolf

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  1. Florian Weissinger
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  2. Holger W. Auner
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  18. Hans H. Wolf
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Correspondence to Florian Weissinger.

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Weissinger, F., Auner, H.W., Bertz, H. et al. Antimicrobial therapy of febrile complications after high-dose chemotherapy and autologous hematopoietic stem cell transplantation—guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol 91, 1161–1174 (2012). https://doi.org/10.1007/s00277-012-1456-8

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