Abstract
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with recognised variability in molecular aetiology and clinical outcome. Though the use of agents such as rituximab significantly improves outcome, intrinsic genetic and morphological factors greatly affect the response to treatment. The objective of this study was to evaluate the prognostic value of immunohistochemical subtyping and the International Prognostic Index (IPI) for predicting treatment outcome in Chinese DLBCL patients. We followed 108 cases of DLBCL and performed prognostic analyses based on molecular subtyping of the disease through immunostaining of tissue samples. The use of rituximab conferred a clinical benefit to DLBCL patients regardless of disease subtype. Importantly, this treatment regimen also improved outcomes in patients with the non-germinal centre B-cell-like (GCB) DLBCL subtype, frequently associated with poorer prognosis. Our results suggest that IPI was the best tool for the prediction of treatment outcome in our patient cohort, regardless of treatment regimen. Furthermore, the use of rituximab alongside classical chemotherapy regimens can improve the outcomes for DLBCL patients who exhibit both GCB and non-GCB subtypes of the disease.
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Acknowledgements
The authors gratefully acknowledge all members of the Shanghai Institute of Hematology for their support and Professor Xin-Xu Du for pathological review. This work was supported in part by the Shanghai Commission of Science and Technology (Grants 44107025 and 05DZ19317), the National Natural Science Foundation of China (Grants 30570777 and 30750335), the Chinese National High Tech Program (Grant 863:2006AA02A301), the Shanghai Commission of Science and Technology (Grant 08410708800), the Program for New Century Excellent Talents in University, and the Fok Ying Tung Education Foundation (Grant 111035). J-ML, Z-GX, W-LZ, and Z-XS contributed to the concept and experimental design of this work. Z-GX and Z-ZX performed the research. S-QZ, FD, YC, Q-SC, YZ, QZ, and J-PH collected the data; interpretation and analysis of the data was performed by Z-GX and J-ML. Z-GX, W-LZ, and J-ML wrote the paper. All authors read and approved the final manuscript.
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Xia, ZG., Xu, ZZ., Zhao, WL. et al. The prognostic value of immunohistochemical subtyping in Chinese patients with de novo diffuse large B-cell lymphoma undergoing CHOP or R-CHOP treatment. Ann Hematol 89, 171–177 (2010). https://doi.org/10.1007/s00277-009-0799-2
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DOI: https://doi.org/10.1007/s00277-009-0799-2