Skip to main content
SpringerLink
Log in

EORTC QLQ-C30 assessment in Turkish patients with hematological malignancies

Association with anxiety and depression

  • Original Article
  • Published:
Annals of Hematology Aims and scope Submit manuscript

Abstract

We aimed to evaluate the prevalences of self-reported anxiety and depression symptoms in hematological malignancy patients and to determine the association between the presence of these disorders and the results of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-30 (EORTC QLQ-C30). One hundred and forty patients with a diagnosis of a hematological malignancy completed the Hospital Anxiety and Depression Scale (HADS) and the General Health Questionnaire. Patients with higher anxiety scores were more frequently inpatients, had higher EORTC general symptom scores, and they had lower cognitive, emotional, social functioning and global quality of life (QoL) scores (all p values <0.05). Patients with higher depression scores had more frequently active disease and were inpatients; they had higher mean Eastern Cooperative Oncology Group performance scores, EORTC gastrointestinal system and general symptom scores, and significantly lower physical, role, emotional, social and cognitive functioning and global QoL scores (all p values <0.01). During follow-up, it was observed that survival curves of patients with active disease who had higher HADS depression scores tended to be shorter than those with lower scores (p = 0.1). Anxiety and depression are frequent in hematological malignancy patients and associated with poor QoL and performance status. In addition, the presence of self-reported depression might have a predictive value for poor prognosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Aaranson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duerz NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes J, Kaasa S, Klee M, Osoba D, Razavi D, Rofe PB, Schraub S, Sneeuw K, Sullivan M, Takeda F (1993) The European Organization for Research and Treatment of Cancer QLQ-30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376

    Article  Google Scholar 

  2. Andrykowski MA, Greiner CB, Altmaier EM, Burish TG, Antin JH, Gingrich R, McGarigle C, Henslee-Downey PJ (1995) Quality of life following bone marrow transplantation: findings from a multi-centre study. Br J Cancer 71:1322–1329

    PubMed  CAS  Google Scholar 

  3. Aydemir O (1997) Validity and reliability of Turkish version of Hospital Anxiety and Depression scale. Turk J Psychiatry 8:280–287

    Google Scholar 

  4. Fayers PM, Aaranson NK, Bjordal K, Groenvold M, Curran D, Bottomley A (2001) on behalf of the EORTC Quality of Life Group The EORTC QLQ-C30 scoring manual (3rd edition). European Organisation for Research and Treatment of Cancer, Brussels

    Google Scholar 

  5. Gulbrandsen N, Hjermstad MJ, Wisloff F (2004) Interpretation of quality of life scores in multiple myeloma by comparison with a reference population and assessment of the clinical importance of score differences. for the Nordic Myeloma Study Group Eur J Haematol 72:172–180

    Article  PubMed  Google Scholar 

  6. Guzelant A, Goksel T, Ozkok S, Tasbakan S, Aysan T, Bottomley A (2004) The European Organization for Research and Treatment of Cancer QLQ-C30: an examination into the cultural validity and reliability of the Turkish version of the EORTC QLQ-C30. Eur J Cancer Care 13:135–144

    Article  CAS  Google Scholar 

  7. Holzner B, Kemmler G, Kopp M, Nguyen-Van-Tam D, Sperner-Unterweger B, Greil R (2004) Quality of life of patients with chronic lymphocytic leukemia: results of a longitudinal investigation over 1 yr. Eur J Haematol 72:381–389

    Article  PubMed  Google Scholar 

  8. Kiecolt-Glaser J, Glaser R (2002) Depression and immune function: central pathways to morbidity and mortality. J Psychosom Res 53:873–876

    Article  PubMed  Google Scholar 

  9. Kiecolt-Glaser JK, McGuire L, Robles TF, Glaser R (2002) Psychoneuroimmunology: psychological influences on immune function and health. J Consult Clin Psychol 70:537–547

    Article  PubMed  Google Scholar 

  10. Kilic C (1996) General health questionnaire: a validity and reliability study. Turk J Psychiatry 7:3–9

    Google Scholar 

  11. Montgomery C, Pocock M, Titley K, Lloyd K (2003) Predicting psychological distress in patients with leukemia and lymphoma. J Psych Resn 54:289–292

    Article  Google Scholar 

  12. Noyes RJ, Holt C, Massie M (1998) Anxiety disorders. In: Holland JC (ed) Psycho-oncology. Oxford University Press, New York, pp 548–563

    Google Scholar 

  13. Osoba D, Aaronson N, Zee B, Sprangers M, te Velde A (1997) Modification of the EORTC QLQ (version 2.0) based on content validity and reliability testing in large samples of patients with cancer. The Study Group on Quality of Life of the EORTC and the Symptom Control and Quality of Life Committees of the NCI of Canada Clinical Trials Group. Qual Life Res 6:103–108

    Article  PubMed  CAS  Google Scholar 

  14. Schleifer SJ, Keller SE, Bond RN, Cohen J, Stein M (1989) Major depressive disorder and immunity. Arch Gen Psychiatry 46:81–87

    PubMed  CAS  Google Scholar 

  15. Schumacher A, Kessler T, Buchner T, Wewers D, van de Loo J (1998) Quality of life in adult patients with acute myeloid leukemia receiving intensive and prolonged chemotherapy—longitudinal study. Leukemia 12:586–592

    Article  PubMed  CAS  Google Scholar 

  16. Spiegel D (1996) Cancer and depression. Br J Psychiatry 168:109–116

    Google Scholar 

  17. Stark D, Kiely M, Smith A, Velikova G, House A, Selby P (2002) Anxiety disorders in cancer patients: their nature, associations, and relation to quality of life. J Clin Oncol 20:3137–3148

    Article  PubMed  CAS  Google Scholar 

  18. Taylor AE, Olver IN, Sivanthan T, Chi M, Purnell C (1999) Observer error in grading performance status in cancer patients. Support Care Cancer 7:332–335

    Article  PubMed  CAS  Google Scholar 

  19. Zigmond AS, Snaith PR (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–370

    Article  PubMed  CAS  Google Scholar 

  20. Zittoun R, Achard S, Rusziewski M (1999) Assessment of quality life during intensive chemotherapy or bone marrow transplantation. Psycho-Oncology 8:64–73

    Article  PubMed  CAS  Google Scholar 

  21. Zubrod CG, Schneiderman M, Frei E, Brindley C, Gold GL, Shnider B, Oviedo R, Gorman J, Jones R, Jonsson U, Colsky J, Chalmers T, Ferguson B, Dederick M, Holland J et al (1960) Cancer—appraisal of methods for the study of chemotherapy of cancer in man: comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide. J Chron Dis 11:7–33

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Hematology, Trakya University Medical Faculty, Edirne, Turkey

    Gülsüm Emel Pamuk, Burhan Turgut, Muzaffer Demir & Özden Vural

  2. Department of Internal Medicine, Trakya University Medical Faculty, Edirne, Turkey

    Ferda Harmandar, Nilay Ermantaş & Orbay Harmandar

  3. Eski Yıldız Cad. Park Apt. No:24 Daire:18, 80700, Beşiktaş-İstanbul, Turkey

    Gülsüm Emel Pamuk

Authors
  1. Gülsüm Emel Pamuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ferda Harmandar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nilay Ermantaş
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Orbay Harmandar
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Burhan Turgut
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Muzaffer Demir
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Özden Vural
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gülsüm Emel Pamuk.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pamuk, G.E., Harmandar, F., Ermantaş, N. et al. EORTC QLQ-C30 assessment in Turkish patients with hematological malignancies. Ann Hematol 87, 305–310 (2008). https://doi.org/10.1007/s00277-008-0445-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-008-0445-4

Keywords

Search

Navigation