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Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma

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Abstract

In patients with hematologic malignancies, granulocyte colony-stimulating factor (G-CSF) following chemotherapy is widely used to mobilize peripheral blood progenitor cells (PBPCs), but there have been no trials comparing schedules of G-CSF following chemotherapy. We conducted a prospective randomized comparative observation of the mobilization with a single dose (10 μg kg once a day) or split dose (5 μg kg twice a day) of lenograstim following chemotherapy in 25 multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma (NHL) patients. Chemotherapy was cyclophosphamide 4 g/m2 for MM and ESHAP with or without Rituximab for NHL. The median number of harvested CD34+ cells was 19.4×106/kg and 15.8×106/kg in the single- and split-dose groups, respectively (p=0.47). Targeted collection of 5×106 CD34+ cells/kg was achieved in 18/20 patients in the single-dose group and in all 20 patients of the split-dose group (p=0.24), with the median number of sessions 1 and 2 in the single- and split-dose groups, respectively (p=0.13). We could not observe statistically significant differences between a single-dose and split-dose lenograstim following chemotherapy in enhancing the mobilization of PBPCs in MM or NHL patients.

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Acknowledgements

We thank the nursing staff of ward 84 for their skillful care of patients receiving autologous stem cell transplantation. We are obliged to the technical staff at the Department of Diagnostic Laboratory Medicine for their excellent cooperation.

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Authors and Affiliations

  1. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Shin Kim, Jung Sun Park, Jungsin Lee & Cheolwon Suh

  2. Department of Internal Medicine, College of Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea

    Hyo-Jung Kim

  3. Department of Diagnostic Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Hyun-Sook Chi & Chan Jeong Park

  4. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Jooryung Huh

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  1. Shin Kim
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Correspondence to Cheolwon Suh.

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Kim, S., Kim, HJ., Park, J.S. et al. Prospective randomized comparative observation of single- vs split-dose lenograstim to mobilize peripheral blood progenitor cells following chemotherapy in patients with multiple myeloma or non-Hodgkin’s lymphoma. Ann Hematol 84, 742–747 (2005). https://doi.org/10.1007/s00277-005-1103-8

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