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FDG-MicroPET and Diffusion-Weighted MR Image Evaluation of Early Changes After Radiofrequency Ablation in Implanted VX2 Tumors in Rabbits

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Abstract

The objective of this study was to evaluate the early changes after radiofrequency ablation (RFA) in VX2 rabbit tumors implanted into the back muscles by diffusion-weighted magnetic resonance (MR) imaging and 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG PET). Percutaneous CT-guided RFA was conducted in seven rabbits with implanted VX2 tumors. VX2 tumors on the other side were untreated and served as the control. MR imaging was performed with a clinical 1.5-T instrument 2 days after RFA, and FDG-PET, using a high-resolution PET scanner for small animals, was obtained 3 days after the procedure. The mean apparent diffusion coefficient (ADC) values and radioactivity count of untreated and ablated tumors were calculated. Untreated VX2 tumors showed hyperintensity on T1-, T2-, and diffusion-weighted MR images, ring-enhanced on contrast-enhanced T1-weighted imaging, and ring-shaped FDG accumulation on FDG-PET. Ablated VX2 tumors showed slight hyperintensity on T1-, T2-, and diffusion-weighed images, slight enhancement on contrast-enhanced T1-weighted images, and low accumulation on FDG-PET. The ADC value of ablated VX2 tumors (1.52 ± 0.24 × 10−3 mm2/s) was significantly higher than that of untreated tumors (1.09 ± 0.12 × 10−3; p < 0.05). The tumor/muscle ratio of ablated tumors (0.5 ± 0.3) was significantly lower than that of untreated tumors (11.6 ± 3.2; p < 0.05). Histopathological examination confirmed the lack of viable tumor cells in the ablated lesions. The results indicate that both ADC value and FDG-PET are potentially useful markers for monitoring the early effects of RFA.

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Acknowledgment

This work was supported by Grant-in Aid for Scientific Research (KAKENHI) 19790892.

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Authors and Affiliations

  1. Department of Radiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan

    Tomohiro Ohira, Tomohisa Okuma, Toshiyuki Matsuoka, Kenji Nakamura & Yuichi Inoue

  2. Molecular Imaging Research Program, RIKEN, Kobe, Japan

    Yasuhiro Wada

  3. Department of Physiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan

    Yasuhiro Wada & Yasuyoshi Watanabe

  4. Frontier Research System, RIKEN, Tokyo, Japan

    Yasuyoshi Watanabe

Authors
  1. Tomohiro Ohira
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  2. Tomohisa Okuma
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  3. Toshiyuki Matsuoka
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  4. Yasuhiro Wada
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  5. Kenji Nakamura
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  6. Yasuyoshi Watanabe
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  7. Yuichi Inoue
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Correspondence to Tomohiro Ohira.

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Ohira, T., Okuma, T., Matsuoka, T. et al. FDG-MicroPET and Diffusion-Weighted MR Image Evaluation of Early Changes After Radiofrequency Ablation in Implanted VX2 Tumors in Rabbits. Cardiovasc Intervent Radiol 32, 114–120 (2009). https://doi.org/10.1007/s00270-008-9394-5

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  • DOI: https://doi.org/10.1007/s00270-008-9394-5

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