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Influence of NaCl Concentrations on Coagulation, Temperature, and Electrical Conductivity Using a Perfusion Radiofrequency Ablation System: An Ex Vivo Experimental Study

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Abstract

Purpose

To determine, by means of an ex vivo study, the effect of different NaCl concentrations on the extent of coagulation obtained during radiofrequency (RF) ablation performed using a digitally controlled perfusion device.

Method

Twenty-eight RF ablations were performed with 40 W for 10 min using continuous NaCl infusion in fresh excised bovine liver. For perfusion, NaCl concentrations ranging from 0 (demineralized water) to 25% were used. Temperature, the amount of energy, and the dimensions of thermal-induced white coagulation were assessed for each ablation. These parameters were compared using the nonparametric Mann-Whitney test. Correlations were calculated according to the Spearman test.

Results

RF ablation performed with 0.9% to 25% concentrations of NaCl produced a mean volume of coagulation of 30.7 ± 3.8 cm3, with a mean short-axis diameter of 3.6 ± 0.2 cm. The mean amount of energy was 21,895 ± 1,674 W and the mean temperature was 85.4 ± 12.8°C. Volume of coagulation, short-axis diameter, and amount of energy did not differ significantly among NaCl concentrations (p > 0.5). A correlation was found between the NaCl concentration and the short-axis diameter of coagulation (r = 0.64) and between the NaCl concentration and the mean temperature (r = 0.67), but not between the NaCl concentration and volume of coagulation.

Conclusion

In an ex vivo model, continuous perfusion with high NaCl concentrations does not significantly improve the volume of thermal-induced coagulation. This may be because the use of a low-power generator cannot sufficiently exploit the potential advantage of better tissue conductivity provided by NaCl perfusion.

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Disclosure

P.L.P. was supported in part through research collaboration with Berchtold and funds from MITT/BMBF project 16SV 1352.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, Eberhard Karls University, Tübingen, Germany

    Christophe Aubé, Diethard Schmidt, Claus D. Claussen & Philippe L. Pereira

  2. Department of Radiology, University Hospital Angers, Angers, France

    Christophe Aubé

  3. Section of Experimental Radiology, Eberhard Karls University, Tübingen, Germany

    Jens Brieger

  4. Department of General and Transplantation Surgery, Eberhard Karls University, Tübingen, Germany

    Martin Schenk

  5. Institute of Pathology, Eberhard Karls University, Tübingen, Germany

    Stefan Kroeber

  6. Department of Biostatistics, University Hospital Angers, Angers, France

    Bruno Vielle

  7. Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

    S. Nahum Goldberg

  8. Department of Radiology, University Hospital of Angers, 4, rue Larrey, 49933, Angers, France

    Christophe Aubé

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  1. Christophe Aubé
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  2. Diethard Schmidt
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Correspondence to Christophe Aubé.

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Aubé, C., Schmidt, D., Brieger, J. et al. Influence of NaCl Concentrations on Coagulation, Temperature, and Electrical Conductivity Using a Perfusion Radiofrequency Ablation System: An Ex Vivo Experimental Study. Cardiovasc Intervent Radiol 30, 92–97 (2007). https://doi.org/10.1007/s00270-006-0091-y

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