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A Simplified Method of Opacifying and Mixing Acrylic Cement for Percutaneous Vertebroplasty: A Clinical and In Vitro Study

  • Clinical Investigations
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Abstract

The objective of this study was to simplify the opacifying mixing process of the bone cement and contrast used for percutaneous vertebroplasty (PVP). We performed a biomechanical study of polymethyl methacrylate (PMMA) (CorinplastTM 3) using three different mixtures of PMMA, monomer, and contrast: group I, 2:1; group II, 3:2; group III, 3:2:1 ratio of powder/monomer/iodinated contrast (Omnipaque). In vitro biomechanical testing of ultimate compressive strength was carried out in all samples. Following the conclusion of a proper bone cement mixture regimen drawn from the in vitro study, PVP was performed in 125 patients: 58 with cancer, 12 with hemangioma, and 54 with osteoporotic fracture. The ultimate compressive strength in group III was decreased by 38% compared to groups II and I. Proper fluoroscopic visualization was achieved in all PVP procedures using this mixture. There were no major complications associated with injection of the cement mixture. Complete (CR) and partial response (PR) was obtained in 64% and 32.8%, respectively. No further vertebral collapse occurred during follow-up. The regimen using iodinated contrast for cement visualization during PVP provides a simple and convenient new method for mixing. Although the biomechanical strength is altered by the contrast medium added, it seems insignificant in clinical practice based on the authors’ limited experience.

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References

  1. P Galibert H Deramond (1990) ArticleTitlePercutaneous acrylic vertebroplasty as a treatment of vertebral angioma as well as painful and debilitating diseases Chirurgie 116 326–334 Occurrence Handle1:STN:280:DyaK3M7itF2htA%3D%3D Occurrence Handle2149096

    CAS  PubMed  Google Scholar 

  2. A Weill J Chiras JM Simon et al. (1996) ArticleTitleSpinal metastases: Indications for and results of percutaneous injection of acrylic surgical cement Radiology 199 241–247 Occurrence Handle1:STN:280:DyaK283gtF2jtA%3D%3D Occurrence Handle10.1148/radiology.199.1.8633152 Occurrence Handle8633152

    Article  CAS  PubMed  Google Scholar 

  3. A Cotten F Dewatre B Cortet et al. (1996) ArticleTitlePercutaneous vertebroplasty for osteolytic metastases and myeloma: Effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow up Radiology 200 525–530 Occurrence Handle1:STN:280:DyaK283psVGqsQ%3D%3D Occurrence Handle10.1148/radiology.200.2.8685351 Occurrence Handle8685351

    Article  CAS  PubMed  Google Scholar 

  4. JD Barr MS Barr TJ Lemley et al. (2000) ArticleTitlePercutaneous vertebroplasty for pain relief and spinal stabilization Spine 25 923–928 Occurrence Handle1:STN:280:DC%2BD3c3jt1Shuw%3D%3D Occurrence Handle10.1097/00007632-200004150-00005 Occurrence Handle10767803

    Article  CAS  PubMed  Google Scholar 

  5. Murphy KJ, Deramond H (2000) Percutaneous vertebroplasty in benign and malignant disease. (Review). Neuroimaging Clin North Am10:535–545

    Google Scholar 

  6. Mathis JM, Wong W (2003) Percutaneous vertebroplasty: technical considerations. J Vasc Intervent Radiol 14:953–960

    Article  Google Scholar 

  7. A Gangi S Guth JP Imbert et al. (2003) ArticleTitlePercutaneous vertebroplasty: indications, technique, and results Radiographics 23 e10 Occurrence Handle10.1148/rg.e10 Occurrence Handle12889460

    Article  PubMed  Google Scholar 

  8. Evans AJ, Jensen ME, Kip KE, et al. (2003) Vertebral compression fractures: Pain reduction and improvement in functional mobility after percutaneous polymethylmethacrylate vertebroplasty retrospective report of 245 cases. Radiology 22:366–372

    Article  Google Scholar 

  9. Perez-Higueras A, Alvarez L, Rossi RE, et al. (2002) Percutaneous vertebroplasty: long-term clinical and radiological outcome. Neuroradiology 44:950–954

    Article  CAS  PubMed  Google Scholar 

  10. McGraw JK, Lippert JA, Minkus KD, et al. (2002) Prospective evaluation of pain relief in 100 patients undergoing percutaneous vertebroplasty: Results and follow-up. J Vasc Intervent Radiol 13:883–886

    Article  Google Scholar 

  11. World Health Organization (WHO) (1990) Cancer Pain Relief and Palliative Care: Report of a WHO Expert Committee. WHO, Geneva

    Google Scholar 

  12. McGraw JK, Cardella J, Barr JD, et al. (2003) Society of Interventional Radiology quality improvement guidelines for percutaneous vertebroplasty. J Vasc Intervent Radiol 14:827–831

    Article  Google Scholar 

  13. Belkoff S, Deramond H, Mathis J, et al. (2000) Vertebroplasty: the biomechanical effect of cement volume (abstract). Trans Orthop Res Soc 25:356

    Google Scholar 

  14. SM Belkoff M Maroney DC Fenton et al. (1999) ArticleTitleAn in vitro biomechanical evaluation of bone cements used in percutaneous vertebroplasty Bone 25 23S–26S Occurrence Handle1:STN:280:DyaK1MzosFCmsw%3D%3D Occurrence Handle10.1016/S8756-3282(99)00128-3 Occurrence Handle10458269

    Article  CAS  PubMed  Google Scholar 

  15. Mathis JM, Barr JD, Belkoff SM, et al. (2001) Percutaneous vertebroplasty: a developing standard of care for vertebral compression fractures. AJNR 22:373–381

    CAS  PubMed  Google Scholar 

  16. C Vasconcelos P Gailloud NJ Beauchamp et al. (2002) ArticleTitleIs percutaneous vertebroplasty without pretreatment venography safe? Evaluation of 205 consecutives procedures AJNR Am J Neuroradiol 23 913–917 Occurrence Handle12063215

    PubMed  Google Scholar 

  17. Hierholzer J, Anselmetti G, Fuchs H, et al. (2003) Percutaneous osteoplasty as a treatment for painful malignant bone lesions of the pelvis and femur. J Vasc Intervent Radiol 14:773–777

    Article  Google Scholar 

  18. WC Peh La Gilula DD Peck (2002) ArticleTitlePercutaneous vertebroplasty for severe osteoporotic vertebral body compression fractures Radiology 223 121–126 Occurrence Handle10.1148/radiol.2231010234 Occurrence Handle11930056

    Article  PubMed  Google Scholar 

  19. Chiras J., Depriester C, Weill A, et al. (1997) Percutaneous vertebral surgery: techniques and indications. J Neuroradiol 24:45–52

    CAS  PubMed  Google Scholar 

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Acknowledgments

The authors thank Dr. Robert F. Jeffery from Dartmouth-Hitchcock Medical Center for his effort on manuscript revision. This study is supported by grant H2014 from the Jiangsu Health Key Project and grant 20024074 from the Nanjing Science and Technique Research Foundation.

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Authors and Affiliations

  1. Department of Radiology, Zhong-Da Hospital, Southeast University, 87# Dingjiaqiao Road, Nanjing, China

    Gao-Jun Teng, Shi-Cheng He, Gang Deng, Jin-He Guo, Wen Fang & Guang-Yu Zhu

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  1. Gao-Jun Teng
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  2. Shi-Cheng He
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  3. Gang Deng
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  4. Jin-He Guo
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Correspondence to Gao-Jun Teng.

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Teng, GJ., He, SC., Deng, G. et al. A Simplified Method of Opacifying and Mixing Acrylic Cement for Percutaneous Vertebroplasty: A Clinical and In Vitro Study. Cardiovasc Intervent Radiol 28, 570–577 (2005). https://doi.org/10.1007/s00270-004-0126-1

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  • DOI: https://doi.org/10.1007/s00270-004-0126-1

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