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Efficacy of Postoperative Transarterial Chemoembolization and Portal Vein Chemotherapy for Patients with Hepatocellular Carcinoma Complicated by Portal Vein Tumor Thrombosis—a Randomized Study

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Abstract

Objectives

The aim of this single, randomized study was to explore the efficacy of postoperative transarterial chemoembolization (TACE) and portal vein chemotherapy (PVC) for patients with hepatocellular carcinoma (HCC) complicated by portal vein tumor thrombosis (PVTT) and to evaluate prognostic factors.

Methods

The study cohort consisted of 112 patients with HCC and PVTT randomly divided into three groups: Group A (37 patients), operation only; Group B (35 patients), operation plus TACE; Group C (40 patients), operation plus TACE and PVC. Disease-free survival rates and prognostic factors were analyzed.

Results

Most of the side effects and complications were related to the operation, catheters, and local chemotherapy and included liver decompensation (15.0%), catheter obstruction (11.6%), and nausea and loss of appetite (22.1%). The disease-free survival curve was significantly different among the three groups, as estimated by the Kaplan-Meier method (both P < 0.05). Group C showed a significantly higher disease-free survival rate than Group A (P < 0.05), but no statistical differences were found between group A and group B, and group B and group C (both P > 0.05). Tumor size, tumor number, PVTT location, and treatment modalities were independent prognostic factors (P < 0.05).

Conclusion

Postoperative TACE combined with PVC may benefit the survival of patients with HCC complicated by PVTT in the short-term (less than 60 months), but long-term efficacy is not yet certain and needs to be confirmed by further studies.

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, Cancer Hospital of Tianjin Medical University, Huanhu Western Road, Hexi District, Tianjin, Tianjin, People’s Republic of China

    Q. Li, J. Wang, Y.L. Cui, J.T. Juzi & X.S. Hao

  2. Department of Pathology, Cancer Hospital of Tianjin Medical University, Tianjin, Tianjin, People’s Republic of China

    Y. Sun

  3. Department of Epidemiology, Cancer Hospital of Tianjin Medical University, Tianjin, Tianjin, People’s Republic of China

    H.X. Li & B.Y. Qian

Authors
  1. Q. Li
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  2. J. Wang
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  3. Y. Sun
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  4. Y.L. Cui
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Correspondence to Q. Li.

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Li, Q., Wang, J., Sun, Y. et al. Efficacy of Postoperative Transarterial Chemoembolization and Portal Vein Chemotherapy for Patients with Hepatocellular Carcinoma Complicated by Portal Vein Tumor Thrombosis—a Randomized Study. World J. Surg. 30, 2004–2011 (2006). https://doi.org/10.1007/s00268-006-0271-6

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  • DOI: https://doi.org/10.1007/s00268-006-0271-6

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