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Hepatectomy for Colorectal Liver Metastases with Macroscopic Intrabiliary Tumor Growth

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Abstract

Objectives

We set out to clarify the clinicopathologic characteristics of colorectal liver metastases with macroscopic intrabiliary tumor growth and to determine optimal surgical management.

Methods

Over 15 years, 6 of 103 patients undergoing hepatectomy for colorectal liver metastases had macroscopic intrabiliary tumor growth and were analyzed retrospectively.

Results

We performed 11 operations for the 6 patients, consisting of 10 hepatectomies (including 1 hepatopancreatoduodenectomy) and 1 pancreatoduodenectomy. Three patients survived more than 5 years: 1 died of pulmonary emphysema with no sign of recurrence 101 months after initial hepatectomy; the 2 others were alive with no sign of recurrence at 74 and 145 months after initial hepatectomy. Median survival time of all 6 patients was 87.5 months. Histologically, intrabiliary tumor growth had two components: intraluminal and intraepithelial extension. In the proximal direction, distance between these two components ranged from 4–10 mm.

Conclusion

Aggressive surgical treatment can improve chances of long-term survival for patients with macroscopic intrabiliary growth of colorectal liver metastasis. Although nonanatomic limited resection is a common procedure for colorectal liver metastasis, anatomic hepatobiliary resection is recommended.

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Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Teiichi Sugiura MD, Masato Nagino MD, Koji Oda MD, Tomoki Ebata MD, Hideki Nishio MD, Toshiyuki Arai MD & Yuji Nimura MD

Authors
  1. Teiichi Sugiura MD
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  2. Masato Nagino MD
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  3. Koji Oda MD
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  4. Tomoki Ebata MD
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  5. Hideki Nishio MD
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  6. Toshiyuki Arai MD
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  7. Yuji Nimura MD
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Corresponding author

Correspondence to Yuji Nimura MD.

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Sugiura, T., Nagino, M., Oda, K. et al. Hepatectomy for Colorectal Liver Metastases with Macroscopic Intrabiliary Tumor Growth. World J. Surg. 30, 1902–1908 (2006). https://doi.org/10.1007/s00268-006-0205-3

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  • DOI: https://doi.org/10.1007/s00268-006-0205-3

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