Skip to main content
SpringerLink
Log in

Resection of liver metastases from colorectal cancer: Are there any truly significant clinical prognosticators?

  • Original Contributions
  • Published:
Diseases of the Colon & Rectum

Abstract

PURPOSE: This study was designed to evaluate the prognostic significance of various prognostic factors affecting recurrence after resection of colorectal hepatic metastases. PATIENTS AND METHODS: Records of 54 patients who had hepatic resection between 1986 and 1993 for metastatic liver tumor from colorectal cancer were reviewed. Factors analyzed were those reported to be of prognostic significance in other studies, including gender, primary tumor site, Dukes stage, diagnostic interval, grade, preoperative carcinoembryonic antigen (CEA) level, number of metastases, size of metastases, distribution of metastases, type of resection, resection margin, and estimated blood loss. RESULTS: Average follow-up of surviving patients was 28 (range, 12–89) months. Average survival time from date of hepatic resection was 26 months, with an estimated actuarial survival rate of 25.5 percent at five years. Using the multivariate analysis of factors, gender and preoperative CEA level were shown to be significantly related to overall survival (P=0.0455 and 0.054, respectively). Cancer of the right side colon had significant correlation with hepatic “recurrence” (P=0.0071). CONCLUSIONS: Female patients and those with preoperative CEA values higher than 20 ng/ml have a better chance of survival following hepatic resection. Cancer of the right colon has a greater tendency for hepatic recurrence than that of the left colon.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Silen W. Hepatic resection for metastases from colorectal carcinoma is of dubious value. Arch Surg 1989;124:1021–2.

    PubMed  Google Scholar 

  2. Scheele J, Stangl R, Altendorf-Hofmann A. Hepatic metastases from colorectal carcinoma: impact of surgical resection on the natural history. Br J Surg 1990;77:1241–6.

    PubMed  Google Scholar 

  3. Adson MA. Resection of liver metastases: when is it worth-while? World J Surg 1987;11:511–20.

    PubMed  Google Scholar 

  4. Hughes KS. Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of indications for resection. Surg 1988;103:278–88.

    Google Scholar 

  5. Nordlinger B, Quilichini M-A, Parc R, Hannoun L, Delva E, Huguet C. Hepatic resection for colorectal liver metastases: influence on survival of preoperative factors and surgery for recurrences in 80 patients. Ann Surg 1987;205:256–63.

    PubMed  Google Scholar 

  6. Stone MD, Cady B, Jenkins RL, Mc Dermott WV, Steele GD Jr. Surgical therapy for recurrent liver metastases from colorectal cancer. Arch Surg 1990;125:718–22.

    PubMed  Google Scholar 

  7. Iwatsuki S, Starzl TE. Personal experience with 411 hepatic resections. Ann Surg 1988;208:421–34.

    PubMed  Google Scholar 

  8. Ekberg H, Tranberg KG, Anderson R. Pattern of recurrence in liver resection for colorectal secondaries. World J Surg 1987;11:541–7.

    PubMed  Google Scholar 

  9. van Ooijen B, Wiggers T, Meijer S,et al. Hepatic resections for colorectal metastases in the Netherlands: a multiinstitutional 10-year study. Cancer 1992;70:28–34.

    PubMed  Google Scholar 

  10. Butler J, Attiyeh FF, Daly J. Hepatic resection for metastases of the colon and rectum. Surg Gynecol Obstet 1986;162:109–14.

    PubMed  Google Scholar 

  11. Cady B, McDermott WV. Major hepatic resection for metachronous metastases from colon cancer. Ann Surg 1985;201:204–1.

    PubMed  Google Scholar 

  12. Vogt P, Raab R, Ringe B, Pichlmayr R. Resection of synchronous liver metastases from colorectal cancer. World J Surg 1991;15:62–7.

    PubMed  Google Scholar 

  13. Scheele J, Stangl R, Altendorf-Hofmann A. Indicators of prognosis after hepatic resection for colorectal secondaries. Surgery 1991;110:13–29.

    PubMed  Google Scholar 

  14. Hohenberger P, Schlag PM, Gerneth T, Herfarth C. Pre- and postoperative carcinoembryonic antigen determinations in hepatic resection for colorectal metastases: predictive value and implications for adjuvant treatment based on multivariate analysis. Ann Surg 1994;219:135–43.

    PubMed  Google Scholar 

  15. Cady B, Stone MD. The role of surgical resection of liver metastases in colorectal carcinoma. Semin Oncol 1991;18:399–406.

    PubMed  Google Scholar 

  16. Steele G, Rarikumar TS. Resection of hepatic metastases from colorectal cancer: biological perspectives. Ann Surg 1989;210:127–38.

    PubMed  Google Scholar 

  17. Cady B, Stone MD, Mc Dermott WV. Technical and biological factors in disease-free survival after hepatic resection for colorectal cancer metastases. Arch Surg 1992;127:561–9.

    PubMed  Google Scholar 

  18. Bozzetti F, Bignami P, Montalto F, Doci R, Gennari L. Repeated hepatic resection for recurrent metastases from colorectal cancer. Br J Surg 1992;79:146–8.

    PubMed  Google Scholar 

  19. Hughes KS, Simon R, Songhorabodi S,et al. Resection of the liver for colorectal carcinoma metastases: a multiinstitutional study of patterns of recurrence. Surg 1986;100:278–84.

    Google Scholar 

  20. Wagner JS, Adson MA, van Heerden JA, Adson MH, Ilstrup DM. The natural history of hepatic metastases from colorectal cancer: a comparison with resective treatment. Ann Surg 1984;199:502–7.

    PubMed  Google Scholar 

Download references

Author information

Author notes

  1. Jeng Yi Wang M.D.

    Present address: Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung College of Medicine, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan, Republic of China

Authors and Affiliations

  1. Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung College of Medicine, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan, Republic of China

    Jy-Ming Chiang M.D., Long-Bin Jeng M.D., Chung Rong Changchien M.D., Jinn Shiun Chen M.D. & Kuan Cheng Hsu M.D.

Authors
  1. Jeng Yi Wang M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jy-Ming Chiang M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Long-Bin Jeng M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chung Rong Changchien M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jinn Shiun Chen M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kuan Cheng Hsu M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Wang, J.Y., Chiang, JM., Jeng, LB. et al. Resection of liver metastases from colorectal cancer: Are there any truly significant clinical prognosticators?. Dis Colon Rectum 39, 847–851 (1996). https://doi.org/10.1007/BF02053981

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02053981

Key words

Search

Navigation