Skip to main content
SpringerLink
Log in

Chlorhexidine Gluconate: An Ideal Scolicidal Agent in the Treatment of Intraperitoneal Hydatidosis?

  • Published:
World Journal of Surgery Aims and scope Submit manuscript

Abstract

Hydatid disease is a parasitic disease that is treated primarily by surgery. The most important complication of surgical treatment is spillage of the contents of the cyst, leading to secondary dissemination. In this study, the effect of chlorhexidine gluconate (Chx-Glu) was investigated in the treatment of experimental intraperitoneal hydatidosis (IPH). IPH was reproduced in 100 Wistar albino rats by inoculation with 1 ml of a suspension contained approximately 1500 viable protoscolices of Echinococcus granulosus following determination of scolicidal activity of chlorhexidine gluconate in vitro. Five minutes after protoscolex inoculation, 5 ml of the scolicidal solution was instilled into the peritoneal cavity: 0.9% NaCl (control group), 4.0% Chx-Glu, 0.4% Chx-Glu, and 0.04% Chx-Glu. After 6 months of follow-up, the rats were sacrificed, and the number of isolated cysts, peroperative and postoperative deaths, and toxicity were evaluated. Cyst formation did not occur in any of the Chx-Glu groups compared to the control group (p < 0.05), whereas it was detected in all of the control rats. In addition, to 4.0% Chx-Glu was found to be more toxic and to cause a high mortality rate compared to the 0.4% and 0.04% Chx-Glu groups and the control group (p < 0.05). Chx-Glu 0.04% was found to be the most potent, nontoxic agent; it is easily available, inexpensive, and highly potent in a short period of time at the low concentration. Chx-Glu 0.04% can be used safely in the treatment of intraperitoneal hydatidosis and hydatid cyst.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4

Similar content being viewed by others

References

  1. DH Taylor DL Morris (1988) ArticleTitleThe current management of hydatid disease Br J. Clin. Pract. 42 401

    Google Scholar 

  2. B Langer (1987) ArticleTitleSurgical treatment of hydatid disease of the liver Br. J. Surg. 74 237

    Google Scholar 

  3. H Mottaghian F Saidi (1978) ArticleTitlePostoperative recurrences of hydatid disease Br. J. Surg. 65 237

    Google Scholar 

  4. M Cakmakci I Sayek (1992) ArticleTitleProphylactic effect of albendazole in experimental peritoneal hydatidosis Hepatogastroenterology 39 424

    Google Scholar 

  5. H Laufhman (1989) ArticleTitleCurrent use of skin and wound cleansers and antiseptics Am. J. Surg. 157 359 Occurrence Handle10.1016/0002-9610(89)90570-9

    Article  Google Scholar 

  6. J Platt RA Jones RA Bucknall (1984) ArticleTitleIntraperitoneal antiseptics in experimental bacterial peritonitis Br. J. Surg. 71 626

    Google Scholar 

  7. A Celdran Uriarte P Inarrea Lasheras JL Marijuan Martin et al. (1991) ArticleTitleEffect of povidone iodine and chlorhexidine on the mortality and bacterial clearance in the abdominal cavity of peritonitis rats Eur. J. Surg. 157 393

    Google Scholar 

  8. S Vallance R Waldron (1985) ArticleTitleAntiseptic vs saline lavage in purulent and faecal peritonitis J. Hosp. Infect. 6 87

    Google Scholar 

  9. AK Amir-Jahed R Fardin A Farzad et al. (1975) ArticleTitleClinical echinococcosis, Ann Surg. 182 541

    Google Scholar 

  10. JM Little MJ Holland H Ekberg (1988) ArticleTitleRecurrence of hydatid disease World J. Surg. 65 700

    Google Scholar 

  11. JL Barros (1978) ArticleTitleHydatid disease of the liver Am. J. Surg. 135 597 Occurrence Handle10.1016/0002-9610(78)90043-0 Occurrence Handle1:STN:280:CSeC2c3kslQ%3D Occurrence Handle637207

    Article  CAS  PubMed  Google Scholar 

  12. InstitutionalAuthorNameWHO Informal Working Group on Echinococcosis. (1996) ArticleTitleBull W.H.O. 74 231

    Google Scholar 

  13. O Gokce C Gokce M Yilmaz et al. (1991) ArticleTitlePovidone-iodine in experimental peritoneal hydatidosis Br. J. Surg. 78 495

    Google Scholar 

  14. JI Landa Garcia E Alonso J Gonzalez-Uriarte et al. (1997) ArticleTitleEvaluation of scolicidal agents in an experimental hydatid disease model Eur. Surg. Res. 29 202

    Google Scholar 

  15. H Besim K Karayalcin O Hamamci et al. (1998) ArticleTitleScolicidal agents in hydatid cyst surgery H.P.B. Surg. 10 347

    Google Scholar 

  16. HH LeVeen FR LeVeen EG LeVeen (1993) ArticleTitleThe mythology of povidone-iodine and the development of self-sterilising plastics Surg. Gynecol. Obstet. 176 183

    Google Scholar 

  17. E Meymerian GW Luttermoser GJ Frayha et al. (1963) ArticleTitleHost-parasite relationships in echinococcosis. X. Laboratory evaluation of chemical scolicides as adjuncts to hydatid surgery Ann. Surg. 158 211

    Google Scholar 

  18. P Magistrelli R Masetti R Coppola et al. (1991) ArticleTitleSurgical treatment of hydatid disease of the liver: a 20-year experience Arch. Surg. 126 518 Occurrence Handle1:STN:280:By6C1c3gtVQ%3D Occurrence Handle2009069

    CAS  PubMed  Google Scholar 

  19. G Djilali A Mahrour T Oussedik et al. (1983) ArticleTitleHydrogen peroxide in the surgery of hydatid cyst Presse Med. 12 235 Occurrence Handle10.1016/0091-7435(83)90201-3

    Article  Google Scholar 

  20. J Belghiti T Perniceni M Kabbej et al. (1991) ArticleTitleComplications of peroperative sterilization of hydatid cysts of the liver: apropos of 6 cases Chirurgie 117 343

    Google Scholar 

  21. C Kayaalp M Balkan C Aydin et al. (2001) ArticleTitleHypertonic saline in hydatid disease World J. Surg. 25 975 Occurrence Handle10.1007/s00268-001-0065-9

    Article  Google Scholar 

  22. M Sonisik A Korkmaz H Besim et al. (1988) ArticleTitleEfficacy of cetrimide-chlorhexidine combination in surgery for hydatid cyst Br. J. Surg. 85 1277 Occurrence Handle10.1046/j.1365-2168.1998.00823.x

    Article  Google Scholar 

  23. A Baraka N Wakid F Yamout (1980) ArticleTitleMethemoglobinemia during surgical excision of hydatid cyst Middle East J. Anaesthesiol. 5 509

    Google Scholar 

  24. DS Gilchrist (1979) ArticleTitleChemical peritonitis after cetrimide washout in hydatid-cyst surgery Lancet 2 1374 Occurrence Handle10.1016/S0140-6736(79)92862-9

    Article  Google Scholar 

  25. P Momblano B Pradere N Jarrige et al. (1984) ArticleTitleMetabolic acidosis induced by cetrimonium bromide Lancet 2 1045 Occurrence Handle10.1016/S0140-6736(84)91147-4

    Article  Google Scholar 

  26. VM Bondar C Rago FL Cottone et al. (2000) ArticleTitleChlorhexidine lavage in the treatment of experimental intra-abdominal infection Arch. Surg. 135 309 Occurrence Handle10.1001/archsurg.135.3.309

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of General Surgery, Cumhuriyet University Hospital, Sivas, 58140, Turkey

    Kenan Puryan M.D., Kursat Karadayi M.D., Omer Topcu M.D., Emel Canbay M.D., Ph.D., Mustafa Turan M.D. & Metin Sen M.D.

  2. Department of Microbiology, Cumhuriyet University Faculty of Medicine, Sivas, 58140, Turkey

    Zeynep Sumer M.D.

  3. Department of General Surgery, Ankara University, Faculty of Medicine, Ankara, 06140, Turkey

    Kaan Karayalcin M.D.

Authors
  1. Kenan Puryan M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kursat Karadayi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Omer Topcu M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Emel Canbay M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zeynep Sumer M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mustafa Turan M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Kaan Karayalcin M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Metin Sen M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kursat Karadayi M.D..

Rights and permissions

Reprints and permissions

About this article

Cite this article

Puryan, K., Karadayi, K., Topcu, O. et al. Chlorhexidine Gluconate: An Ideal Scolicidal Agent in the Treatment of Intraperitoneal Hydatidosis?. World J. Surg. 29, 227–230 (2005). https://doi.org/10.1007/s00268-004-7587-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00268-004-7587-x

Keywords

Search

Navigation