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Povidone iodine versus silver nitrate in induction of sclerosing cholangitis in hepatic hydatid cysts surgery

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Abstract

There are several scolicidal agents for inactivation of hydatid cyst protoscolices during surgery, but most of them are associated with adverse side effects such as sclerosing cholangitis and liver necrosis. The present study aims to evaluate the adverse effects of povidone iodine versus silver nitrate in producing sclerosing cholangitis in animal model. Twenty guinea pigs weighing 250–350 g were used in this study. In one group, 0.3 ml 10% povidone iodine was used for 5 min in the biliary tree while in the second group, 0.3 ml 0.5% silver nitrate was used for the same amount of time. After 4 months, the animals were euthanized, and the livers, common bile ducts, and duodenums were resected and immediately sent for cholangiographic studies. Eight animals showed sclerosing cholangitis in the povidone iodine group (80%), whereas only two showed (20%) sclerosing cholangitis in the silver nitrate group. The difference between the two groups was statistically significant. There was a significant risk of sclerosing cholangitis after administration of 10% povidone iodine as a protoscolicidal agent.

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Acknowledgments

We would like to thank the office of Vice-Chancellor for Research of Shiraz University of Medical Sciences for financial support and for main staff in the Laboratory Animal Research center of Shiraz University of Medical Sciences for their cooperation.

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Authors and Affiliations

  1. Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Seyed Vahid Hosseini & Hajar Khazraei

  2. Department of Surgery, College of Medicine, Kerbala University, Kerbala, Iraq

    Abdulrazzak Kalaf Hassan

  3. Department of Surgery, Al-hussain Medical City, Kerbala, Iraq

    Ahmed Mohamed Ali Hussein Alhurry

  4. Pathology department, Shiraz University of Medical Sciences, Shiraz, Iran

    Maral Mokhtari

  5. Transgenic Research Centers, Shiraz University of Medical Sciences, Shiraz, Iran

    Nader Tanideh

  6. Radiology Research Center, Radiology Department, Shiraz University of Medical Sciences, Shiraz, Iran

    Sepideh Sefidbakht

Authors
  1. Seyed Vahid Hosseini
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  2. Abdulrazzak Kalaf Hassan
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  3. Ahmed Mohamed Ali Hussein Alhurry
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  4. Maral Mokhtari
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  5. Nader Tanideh
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  6. Sepideh Sefidbakht
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  7. Hajar Khazraei
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Corresponding author

Correspondence to Hajar Khazraei.

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The authors declare that they have no conflict of interest.

Ethical approval

This article does contain studies with animals performed by the authors, and the study protocol was approved by Ethics Committee of Shiraz University of Medical Sciences according to the principles of laboratory animal care (no. 10226).

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Hosseini, S.V., Kalaf Hassan, A., Alhurry, A.M.A. et al. Povidone iodine versus silver nitrate in induction of sclerosing cholangitis in hepatic hydatid cysts surgery. Comp Clin Pathol 27, 239–243 (2018). https://doi.org/10.1007/s00580-017-2584-2

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  • DOI: https://doi.org/10.1007/s00580-017-2584-2

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