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Systemic Inflammatory Reaction After Silicone Breast Implant

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Abstract

Background

Systemic inflammation after augmentation mammaplasty with modern silicone implants is not currently recognized. In a prospective controlled study, C-reactive protein and other variables were monitored, aiming to test this hypothesis in a young cohort of patients.

Methods

Females (18-30 years old, BMI = 18.5-30 kg/m2, N = 52) were consecutively recruited for breast implant (n = 24, Group I) and for abdominal liposuction (n = 28, Group II/Controls). Patients were interviewed at baseline and followed until 6 months after operation. Variables included demographic and clinical information, surgical outcome, inflammatory markers and autoantibodies.

Results

Operations were well tolerated, without surgical or infectious complications. Mean prosthesis size was 258 ± 21 ml (range = 220-280) and mean aspirate of liposuction was 1972 ± 499 ml (range = 1200-3000). Preoperative, 2-month, and 6-month C-reactive protein concentrations for breast implant patients were 1.3 ± 1.2, 4.8 ± 3.0, and 4.3 ± 6.4 mg/l and for liposuction 3.5 ± 2.7, 3.5 ± 2.1, and 2.2 ± 2.2 mg/l, respectively. Change at 2 months was significant (p = 0.001). Autoantibody investigation failed to reveal remarkable aberrations, except for anticardiolipin elevation, which was nearly symmetrical in the two groups.

Conclusion

C-reactive protein levels increased after operation and correlated with proinflammatory and procoagulatory indices. A mild increase in anticardiolipin IgM occurred but differences between populations were lacking. Despite excellent cosmetic outcomes and lack of complications, acute phase reaction could signal ongoing immunogenicity of silicone and long-term monitoring is recommended.

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Authors and Affiliations

  1. Plastic Surgery Service, Sao Paulo University Medical School, Sao Paulo, Brazil

    Maira M. Silva, Miguel Modolin, Cintia B. Zandona, Wilson Cintra Jr., Rolf Gemperli & Marcos C. Ferreira

  2. Nutrition and Metabolism Unit, Sao Paulo University Medical School, Sao Paulo, Brazil

    Joel Faintuch & Camila M. Yamaguchi

  3. Institute of Biomedical Sciences, Sao Paulo University Medical School, Sao Paulo, Brazil

    Haroldo Fujiwara & Rui Curi

  4. Hospital das Clinicas, II Surgical Division, Avenida Eneias C. Aguiar 255- ICHC- 9th Floor, Room 9077, São Paulo, SP, 05403-900, Brazil

    Joel Faintuch

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  1. Maira M. Silva
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  2. Miguel Modolin
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  3. Joel Faintuch
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  5. Cintia B. Zandona
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Correspondence to Joel Faintuch.

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Silva, M.M., Modolin, M., Faintuch, J. et al. Systemic Inflammatory Reaction After Silicone Breast Implant. Aesth Plast Surg 35, 789–794 (2011). https://doi.org/10.1007/s00266-011-9688-x

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  • DOI: https://doi.org/10.1007/s00266-011-9688-x

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