Abstract
Purpose
To determine whether platelet-rich plasma (PRP) injections are associated with improved pain and function scores when compared with corticosteroid injections for plantar fasciopathy.
Methods
A systematic review of published literature was performed for studies comparing PRP injections and corticosteroid injections for plantar fasciopathy. Studies were assessed using the Cochrane Risk of Bias Tool and the Newcastle Ottawa Scale (NOS). The primary endpoint was pain and function score at three and six month follow-up. Sensitivity analysis was performed for high quality studies and randomised studies.
Results
Ten studies totalling 517 patients were included. Seven studies were randomised. All studies included patients who had failed conservative measures and excluded patients with systemic illness and other causes of foot pain. Studies reported outcomes using the visual analogue score (VAS) and American Orthopaedic Foot and Ankle Score (AOFAS). At 3-month follow-up, PRP injections were associated with improved VAS scores (standard mean difference [SMD], -0.66; 95% CI, -1.3 to -0.02; p = 0.04) and AOFAS scores (SMD, 1.87; 95% CI, 0.16–3.58; p = 0.03). At 6-month follow-up, there was no difference in VAS score (SMD, -0.66; 95% CI, -1.65 to 0.3; p = 0.17) or AOFAS scores (SMD, 1.69; 95% CI, -1.06 to 4.45; p = 0.23). No studies reported adverse event rates or cost analysis. There was no difference in pain or function score at one, six- or 12-month follow-up. Sensitivity analyses of high-quality studies showed no differences between the PRP and steroid group at any of the follow-up points.
Conclusions
PRP injections are associated with improved pain and function scores at three month follow-up when compared with corticosteroid injections. Information regarding relative adverse event rates and cost implications is lacking. Further, large-scale, high-quality, randomised controlled trials with blinding of outcome assessment and longer follow-up are required.
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References
Riddle DL, Schappert SM (2004) Volume of ambulatory care visits and patterns of care for patients diagnosed with plantar fasciitis: a national study of medical doctors. Foot Ankle Int 25(5):303–310
Astrom M, Rausing A (1995) Chronic Achilles tendinopathy. A survey of surgical and histopathologic findings. Clin Orthop Relat Res 316:151–164
Lyras DN, Kazakos K, Verettas D, Polychronidis A, Tryfonidis M, Botaitis S, Agrogiannis G, Simopoulos C, Kokka A, Patsouris E (2009) The influence of platelet-rich plasma on angiogenesis during the early phase of tendon healing. Foot Ankle Int 30(11):1101–1106. doi:10.3113/FAI.2009.1101
Lynch DM, Goforth WP, Martin JE, Odom RD, Preece CK, Kotter MW (1998) Conservative treatment of plantar fasciitis. A prospective study. J Am Podiatr Med Assoc 88(8):375–380. doi:10.7547/87507315-88-8-375
Young CC, Rutherford DS, Niedfeldt MW (2001) Treatment of plantar fasciitis. Am Fam Physician 63(3):467–474, 77-8
Digiovanni BF, Nawoczenski DA, Malay DP, Graci PA, Williams TT, Wilding GE, Baumhauer JF (2006) Plantar fascia-specific stretching exercise improves outcomes in patients with chronic plantar fasciitis. A prospective clinical trial with two-year follow-up. J Bone Joint Surg Am 88(8):1775–1781. doi:10.2106/jbjs.e.01281
Toomey EP (2009) Plantar heel pain. Foot Ankle Clin 14(2):229–245. doi:10.1016/j.fcl.2009.02.001
Crawford F, Atkins D, Young P, Edwards J (1999) Steroid injection for heel pain: evidence of short-term effectiveness. A randomized controlled trial. Rheumatology (Oxford) 38(10):974–977
Gudeman SD, Eisele SA, Heidt RS Jr, Colosimo AJ, Stroupe AL (1997) Treatment of plantar fasciitis by iontophoresis of 0.4% dexamethasone. A randomized, double-blind, placebo-controlled study. Am J Sports Med 25(3):312–316
Coombes BK, Bisset L, Vicenzino B (2010) Efficacy and safety of corticosteroid injections and other injections for management of tendinopathy: a systematic review of randomised controlled trials. Lancet 376(9754):1751-1767. doi:10.1016/S0140-6736(10)61160-9
Wheeler P, Boyd K, Shipton M (2014) Surgery for patients with recalcitrant plantar fasciitis: good results at short-, medium-, and long-term follow-up. Orthop J Sports Med 2(3):2325967114527901. doi:10.1177/2325967114527901
Fitzpatrick J, Bulsara M, Zheng MH (2016) Effectiveness of platelet-rich plasma in the treatment of tendinopathy: response. Am J Sports Med 44(10):NP55–NP56. doi:10.1177/0363546516669322
Arnoczky SP, Sheibani-Rad S (2013) The basic science of platelet-rich plasma (PRP): what clinicians need to know. Sports Med Arthrosc 21(4):180–185. doi:10.1097/JSA.0b013e3182999712
Kajikawa Y, Morihara T, Sakamoto H, Matsuda K, Oshima Y, Yoshida A, Nagae M, Arai Y, Kawata M, Kubo T (2008) Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol 215(3):837–845. doi:10.1002/jcp.21368
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62(10):e1–e34. doi:10.1016/j.jclinepi.2009.06.006
Aksahin E, Dogruyol D, Yuksel HY, Hapa O, Dogan O, Celebi L, Bicimoglu A (2012) The comparison of the effect of corticosteroids and platelet-rich plasma (PRP) for the treatment of plantar fasciitis. Arch Orthop Trauma Surg 132(6):781–785. doi:10.1007/s00402-012-1488-5
Acosta-Olivo C, Elizondo-Rodriguez J, Lopez-Cavazos R, Vilchez-Cavazos F, Simental-Mendia M, Mendoza-Lemus O (2016) Plantar fasciitis. A comparison of treatment with intralesional steroids versus platelet-rich plasma (PRP). A randomized, blinded study. J Am Podiatr Med Assoc. doi:10.7547/15-125
Jain K, Murphy PN, Clough TM (2015) Platelet rich plasma versus corticosteroid injection for plantar fasciitis: a comparative study. Foot (Edinb) 25(4):235–237. doi:10.1016/j.foot.2015.08.006
Mahindra P, Yamin M, Selhi HS, Singla S, Soni A (2016) Chronic plantar fasciitis: effect of platelet-rich plasma, corticosteroid, and placebo. Orthopedics 39(2):e285–e289. doi:10.3928/01477447-20160222-01
Monto RR (2014) Platelet-rich plasma efficacy versus corticosteroid injection treatment for chronic severe plantar fasciitis. Foot Ankle Int 35(4):313–318. doi:10.1177/1071100713519778
Omar AS, Ibrahim ME, Ahmed AS, Said M (2012) Local injection of autologous platelet rich plasma and corticosteroid in treatment of lateral epicondylitis and plantar fasciitis: randomized clinical trial. Egypt Rheumatol 34(2):43–49
Say F, Gurler D, Inkaya E, Bulbul M (2014) Comparison of platelet-rich plasma and steroid injection in the treatment of plantar fasciitis. Acta Orthop Traumatol Turc 48(6):667–672. doi:10.3944/aott.2014.13.0142
Sherpy NA, Hammad MA, Hagrass HA, Samir H, Abu-ElMaaty SE, Mortada MA (2016) Local injection of autologous platelet rich plasma compared to corticosteroid treatment of chronic plantar fasciitis patients: a clinical and ultrasonographic follow-up study. Egypt Rheumatol 38(3)247-252
Shetty VD, Dhillon M, Hegde C, Jagtap P, Shetty S (2014) A study to compare the efficacy of corticosteroid therapy with platelet-rich plasma therapy in recalcitrant plantar fasciitis: a preliminary report. Foot Ankle Surg 20(1):10–13. doi:10.1016/j.fas.2013.08.002
Tiwari M, Bhargava R (2013) Platelet rich plasma therapy: a comparative effective therapy with promising results in plantar fasciitis. J Clin Orthop Trauma 4(1):31–35. doi:10.1016/j.jcot.2013.01.008
Sadiqi S, Lehr AM, Post MW, Vaccaro AR, Dvorak MF, Oner FC (2015) Toward a specific outcome instrument for spinal trauma: how to measure function and health. Spine (Phila Pa 1976) 40(10):E578–E586. doi:10.1097/BRS.0000000000000852
Ibrahim T, Beiri A, Azzabi M, Best AJ, Taylor GJ, Menon DK (2007) Reliability and validity of the subjective component of the American Orthopaedic Foot and Ankle Society clinical rating scales. J Foot Ankle Surg 46(2):65–74. doi:10.1053/j.jfas.2006.12.002
Khan KM, Cook JL, Bonar F, Harcourt P, Astrom M (1999) Histopathology of common tendinopathies. Update and implications for clinical management. Sports Med 27(6):393–408
Khan KM, Cook JL, Kannus P, Maffulli N, Bonar SF (2002) Time to abandon the “tendinitis” myth. BMJ 324(7338):626–627
Anitua E, Pino A, Orive G (2016) Plasma rich in growth factors promotes dermal fibroblast proliferation, migration and biosynthetic activity. J Wound Care 25(11):680–687. doi:10.12968/jowc.2016.25.11.680
Wang JH, Nirmala X (2016) Application of tendon stem/progenitor cells and platelet-rich plasma to treat tendon injuries. Oper Tech Orthop 26(2):68–72. doi:10.1053/j.oto.2015.12.008
Hamilton B, Tol JL, Knez W, Chalabi H (2015) Exercise and the platelet activator calcium chloride both influence the growth factor content of platelet-rich plasma (PRP): overlooked biochemical factors that could influence PRP treatment. Br J Sports Med 49(14):957–960. doi:10.1136/bjsports-2012-091916
Karls SL, Snyder KR, Neibert PJ (2016) Effectiveness of corticosteroid injections in the treatment of plantar fasciitis. J Sport Rehabil 25(2):202–207. doi:10.1123/jsr.2014-0234
Li Z, Xia C, Yu A, Qi B (2014) Ultrasound- versus palpation-guided injection of corticosteroid for plantar fasciitis: a meta-analysis. PLoS One 9(3):e92671. doi:10.1371/journal.pone.0092671
Brinks A, Koes BW, Volkers AC, Verhaar JA, Bierma-Zeinstra SM (2010) Adverse effects of extra-articular corticosteroid injections: a systematic review. BMC Musculoskelet Disord 11:206. doi:10.1186/1471-2474-11-206
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• Study conception and design: P.S., S.M., J.S.B.
• Acquisition of data: P.S., S.M.
• Analysis and interpretation of data: P.S., S.M., J.S.B.
• Writing manuscript: P.S., S.M., J.S.B., I.G.
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Singh, P., Madanipour, S., Bhamra, J.S. et al. A systematic review and meta-analysis of platelet-rich plasma versus corticosteroid injections for plantar fasciopathy. International Orthopaedics (SICOT) 41, 1169–1181 (2017). https://doi.org/10.1007/s00264-017-3470-x
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DOI: https://doi.org/10.1007/s00264-017-3470-x