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The feasibility of ultra-early and fast total‑body [68 Ga]Ga-FAPI-04 PET/CT scan

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

[68 Ga]Ga-FAPI-04 PET/CT has been widely used in oncology patients. The patients need to lie still for 20–30 min during scan after waiting for 60 min post-tracer injection in traditional [68 Ga]Ga-FAPI-04 PET/CT scan. This is difficult for some patients who are intolerant to prolonged horizontal positioning and waiting time. Therefore, we evaluated the diagnostic value of the images obtained in ultra-early and fast scan (5-min p.i., 30-s acquisition time) by the total-body [68 Ga]Ga-FAPI-04 PET/CT and to investigate whether they could meet the requirements of clinical diagnosis.

Methods

Total-body [68 Ga]Ga-FAPI-04 PET/CT was conducted in 12 patients at the Renji Hospital. Patients underwent PET with two acquisitions: 5-min p.i. and 30-s acquisition time (ultra-early and fast imaging) and 60-min p.i. and 300-s acquisition time (traditional imaging). Mean [68 Ga]Ga-FAPI-04 injection dose was 1.85 MBq/kg.

Results

Forty-four lesions were detected in 12 patients on traditional imaging. All the 44 lesions on conventional imaging could also detected by ultra-early and fast imaging. For all the 12 patients, the tumor stage did not change, as same lesions were visible for every case in both images. There was no statistically significant difference in SUVmax of lesions between ultra-early and fast imaging and traditional imaging (12.5 ± 8.7 vs 13.7 ± 8.5, P = 0.528). Background bloodpool (4.0 ± 0.6 vs 0.9 ± 0.2, P < 0.001)and liver (2.5 ± 0.7 vs 1.0 ± 0.5, P < 0.001)at traditional imaging showed a significant decrease in SUVmean compared to ultra-early and fast imaging.

Conclusions

Ultra-early and fast imaging versus traditional [68 Ga]Ga-FAPI-04 imaging resulted in equivalent tumor detection and lesion uptake. Ultra-early and fast total-body [68 Ga]Ga-FAPI-04 PET/CT scan could meet clinical diagnostic requirements for patients with poor tolerant to prolonged horizontal positioning and waiting time.

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Data availability

The data could be obtained from the corresponding author upon request.

References

  1. Lindner T, Loktev A, Altmann A, et al. Development of quinoline-based theranostic ligands for the targeting of fibroblast activation protein. J Nucl Med. 2018;59:1415–22.

    Article  CAS  Google Scholar 

  2. Loktev A, Lindner T, Mier W, et al. A tumor-imaging method targeting cancer-associated fibroblasts. J Nucl Med. 2018;59:1423–9.

    Article  CAS  Google Scholar 

  3. Treglia G, Muoio B, Roustaei H, Kiamanesh Z, Aryana K, Sadeghi R. Head-to-head comparison of fibroblast activation protein inhibitors (FAPI) radiotracers versus [(18)F]F-FDG in oncology: a systematic review. Int J Mol Sci 2021;22

  4. Kuten J, Levine C, Shamni O, et al. Head-to-head comparison of [(68)Ga]Ga-FAPI-04 and [(18)F]-FDG PET/CT in evaluating the extent of disease in gastric adenocarcinoma. Eur J Nucl Med Mol Imaging. 2022;49:743–50.

    Article  CAS  Google Scholar 

  5. Giesel FL, Kratochwil C, Schlittenhardt J, et al. Head-to-head intra-individual comparison of biodistribution and tumor uptake of (68)Ga-FAPI and (18)F-FDG PET/CT in cancer patients. Eur J Nucl Med Mol Imaging. 2021;48:4377–85.

    Article  CAS  Google Scholar 

  6. Qin C, Liu F, Huang J, et al. A head-to-head comparison of (68)Ga-DOTA-FAPI-04 and (18)F-FDG PET/MR in patients with nasopharyngeal carcinoma: a prospective study. Eur J Nucl Med Mol Imaging. 2021;48:3228–37.

    Article  CAS  Google Scholar 

  7. Pang Y, Zhao L, Luo Z, et al. Comparison of (68)Ga-FAPI and (18)F-FDG uptake in gastric, duodenal, and colorectal cancers. Radiology. 2021;298:393–402.

    Article  Google Scholar 

  8. Zhao L, Pang Y, Zheng H, et al. Clinical utility of [(68)Ga]Ga-labeled fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography for primary staging and recurrence detection in nasopharyngeal carcinoma. Eur J Nucl Med Mol Imaging. 2021;48:3606–17.

    Article  CAS  Google Scholar 

  9. Qin C, Shao F, Gai Y, et al. (68)Ga-DOTA-FAPI-04 PET/MR in the evaluation of gastric carcinomas: comparison with (18)F-FDG PET/CT. J Nucl Med. 2022;63:81–8.

    Article  CAS  Google Scholar 

  10. Shi X, Xing H, Yang X, et al. Comparison of PET imaging of activated fibroblasts and (18)F-FDG for diagnosis of primary hepatic tumours: a prospective pilot study. Eur J Nucl Med Mol Imaging. 2021;48:1593–603.

    Article  CAS  Google Scholar 

  11. Badawi RD, Shi H, Hu P, et al. First human imaging studies with the EXPLORER total-body PET scanner. J Nucl Med. 2019;60:299–303.

    Article  CAS  Google Scholar 

  12. Zhang X, Zhou J, Cherry SR, Badawi RD, Qi J. Quantitative image reconstruction for total-body PET imaging using the 2-meter long EXPLORER scanner. Phys Med Biol. 2017;62:2465–85.

    Article  CAS  Google Scholar 

  13. Zhang X, Xie Z, Berg E, et al. Total-body dynamic reconstruction and parametric imaging on the uEXPLORER. J Nucl Med. 2020;61:285–91.

    Article  CAS  Google Scholar 

  14. Wen J, Zhu Y, Li L, Liu J, Chen Y, Chen R. Determination of optimal (68) Ga-PSMA PET/CT imaging time in prostate cancers by total-body dynamic PET/CT. Eur J Nucl Med Mol Imaging. 2022;49:2086–95.

    Article  CAS  Google Scholar 

  15. Zhang X, Cherry SR, Xie Z, Shi H, Badawi RD, Qi J. Subsecond total-body imaging using ultrasensitive positron emission tomography. Proc Natl Acad Sci U S A. 2020;117:2265–7.

    Article  CAS  Google Scholar 

  16. Zhang YQ, Hu PC, Wu RZ, et al. The image quality, lesion detectability, and acquisition time of (18)F-FDG total-body PET/CT in oncological patients. Eur J Nucl Med Mol Imaging. 2020;47:2507–15.

    Article  Google Scholar 

  17. Meyer C, Dahlbom M, Lindner T, et al. Radiation dosimetry and biodistribution of (68)Ga-FAPI-46 PET imaging in cancer patients. J Nucl Med. 2020;61:1171–7.

    Article  CAS  Google Scholar 

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Funding

This work was supported by the National Key R&D Program of China (No. 2021YFA0910004) and the National Natural Science Foundation of China (No. 82171972).

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Author notes

  1. Ruohua Chen and Xinlan Yang contributed equally in the making of this work.

Authors and Affiliations

  1. Department of Nuclear Medicine, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China

    Ruohua Chen, Xiaofeng Yu, Xiang Zhou, Yumei Chen, Lianghua Li, Gang Huang & Jianjun Liu

  2. Central Research Institute, United Imaging Healthcare Group Co, Ltd, Shanghai, China

    Xinlan Yang, Yee Ling Ng & Yun Zhou

Authors
  1. Ruohua Chen
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  2. Xinlan Yang
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  3. Xiaofeng Yu
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  4. Xiang Zhou
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  6. Yumei Chen
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  7. Lianghua Li
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  9. Gang Huang
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Corresponding authors

Correspondence to Gang Huang or Jianjun Liu.

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Ethics approval

The study involving human participants was in line with principles of the ethics committee in Renji Hospital and the Declaration of Helsinki in 1964. Animal-based research was not included in this study.

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Chen, R., Yang, X., Yu, X. et al. The feasibility of ultra-early and fast total‑body [68 Ga]Ga-FAPI-04 PET/CT scan. Eur J Nucl Med Mol Imaging 50, 661–666 (2023). https://doi.org/10.1007/s00259-022-06004-3

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  • DOI: https://doi.org/10.1007/s00259-022-06004-3

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