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Predictive and prognostic value of metabolic tumour volume and total lesion glycolysis in solid tumours

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Abstract

Data available in patients suffering from squamous cell carcinoma of the head and neck, lung carcinoma, oesophageal carcinoma and gynaecological malignancies suggest that metabolic tumour volume and to a lesser extent total lesion glycolysis have the potential to become valuable in the imaging of human solid tumours as prognostic biomarkers for short- to intermediate-term survival outcomes, adding value to clinical staging, for assessment of response to treatment with neoadjuvant and concurrent chemotherapy, and for treatment optimization; for example, based on early treatment response assessment using changes in metabolic tumour volume over time, it might be possible to select patients who require a more aggressive treatment to improve their outcome. Prospective studies enrolling consecutive patients, adopting standardized protocols for FDG PET acquisition and processing, adjusting for potential confounders in the analysis (tumour size and origin) and determining the optimal methodology for determination of these novel markers are mandatory.

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Authors and Affiliations

  1. Department of Nuclear Medicine, P7, University Hospital Ghent, De Pintelaan 185-B, 9000, Ghent, Belgium

    Christophe Van de Wiele

  2. Division of Medical Oncology, Department of Internal medicine, University Hospital Ghent, Ghent, Belgium

    Vibeke Kruse & Peter Smeets

  3. Department of Radiology, University Hospital Ghent, Ghent, Belgium

    Peter Smeets

  4. Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa

    Mike Sathekge

  5. Department of Nuclear Medicine, AZ Groeninge, Kortrijk, Belgium

    Alex Maes

  6. Department of Morphology and Medical Imaging, University Hospital Leuven, Leuven, Belgium

    Alex Maes

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Van de Wiele, C., Kruse, V., Smeets, P. et al. Predictive and prognostic value of metabolic tumour volume and total lesion glycolysis in solid tumours. Eur J Nucl Med Mol Imaging 40, 290–301 (2013). https://doi.org/10.1007/s00259-012-2280-z

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