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Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: validation of an elastic surface model approach in comparison to cardiac magnetic resonance imaging, 4D-MSPECT and QGS

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Abstract

Purpose

The segmentation algorithm ESM based on an elastic surface model was validated for the assessment of left ventricular volumes and ejection fraction from ECG-gated myocardial perfusion SPECT. Additionally, it was compared with the commercially available quantification packages 4D-MSPECT and QGS. Cardiac MRI was used as the reference method.

Methods

SPECT and MRI were performed on 70 consecutive patients with suspected or proven coronary artery disease. End-diastolic (EDV) and end-systolic (ESV) volumes and left ventricular ejection fraction (LVEF) were derived from SPECT studies by using the segmentation algorithms ESM, 4D-MSPECT and QGS and from cardiac MRI.

Results

ESM-derived values for EDV and ESV correlated well with those from cardiac MRI (correlation coeffients R = 0.90 and R = 0.95, respectively), as did the measurements for LVEF (R = 0.86). Both EDV and ESV were slightly overestimated for larger ventricles but not for smaller ventricles; LVEF was slightly overestimated irrespective of ventricle size. The above correlation coefficients are comparable to those for the 4D-MSPECT and QGS segmentation algorithms. However, results obtained with the three segmentation algorithms are not interchangeable.

Conclusion

The ESM algorithm can be used to assess EDV, ESV and LVEF from gated perfusion SPECT images. Overall, the performance was similar to that of 4D-MSPECT and QGS when compared with cardiac MRI. Results obtained with the three tested segmentation methods are not interchangeable, so that the same algorithm should be used for follow-up studies and control subjects.

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Acknowledgements

This work was supported in part by grants from the Deutsche Forschungsgemeinschaft (DFG), Sonderforschungsbereich 656 MoBil Münster (projects C2 and PM3), the Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Münster, and the Bundesministerium für Bildung und Forschung, BIOMAT (TV20/21, BMBF No. 01 KS9503/9). All institutions are from Germany.

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Authors and Affiliations

  1. Department of Nuclear Medicine, University Hospital, Westfälische Wilhelms-University Münster, Münster, Germany

    Lars Stegger, Peter Kies, Otmar Schober & Michael Schäfers

  2. Department of Nuclear Medicine, University Hospital,Aachen University of Technology, Aachen, Germany

    Claudia S. A. Lipke, Bernd Nowak, Udalrich Buell & Wolfgang M. Schaefer

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  1. Lars Stegger
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  2. Claudia S. A. Lipke
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  3. Peter Kies
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  4. Bernd Nowak
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  8. Wolfgang M. Schaefer
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Correspondence to Lars Stegger.

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Stegger, L., Lipke, C.S.A., Kies, P. et al. Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: validation of an elastic surface model approach in comparison to cardiac magnetic resonance imaging, 4D-MSPECT and QGS. Eur J Nucl Med Mol Imaging 34, 900–909 (2007). https://doi.org/10.1007/s00259-006-0322-0

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  • DOI: https://doi.org/10.1007/s00259-006-0322-0

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