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Capacity of lactic acid bacteria in immunity enhancement and cancer prevention

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Abstract

Lactic acid bacteria are associated with the human gastrointestinal tract. They are important for maintaining the balance of microflora in the human gut. An increasing number of published research reports in recent years have denoted the importance of producing interferon-gamma and IgA for treatment of disease. These agents can enhance the specific and nonspecific immune systems that are dependent on specific bacterial strains. The mechanisms of these effects were revealed in this investigation, where the cell walls of these bacteria were modulated by the cytokine pathways, while the whole bacterial cell mediated the host cell immune system and regulated the production of tumor necrosis factors and interleukins. A supplement of highly active lactic acid bacteria strains provided significant potential to enhance host’s immunity, offering prevention from many diseases including some cancers. This review summarizes the current understanding of the function of lactic acid bacteria immunity enhancement and cancer prevention.

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Acknowledgements

This study was supported by the National Key Technology R&D Program (grant number 2015BAD16B02) and National Natural Science Foundation of China (NSFC) (grant number 31201408 and grant number 31471718).

Author’s contributions

Muhammad Shahid Riaz Rajoka and Junling Shi were responsible for writing the review. Jing Zhu and Dongyan Shao assisted in providing references for the manuscript. Qingsheng Huang, Hui Yang, and Mingliang Jin did the final proofreading of the manuscript. All author’s reviewed the manuscript.

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  1. Key Laboratory for Space Bioscience and Space Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, Shaanxi, People’s Republic of China

    Muhammad Shahid Riaz Rajoka, Junling Shi, Jing Zhu, Dongyan Shao, Qingsheng Huang, Hui Yang & Mingliang Jin

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  1. Muhammad Shahid Riaz Rajoka
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Riaz Rajoka, M.S., Shi, J., Zhu, J. et al. Capacity of lactic acid bacteria in immunity enhancement and cancer prevention. Appl Microbiol Biotechnol 101, 35–45 (2017). https://doi.org/10.1007/s00253-016-8005-7

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