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Expression and regulation of genes encoding lignocellulose-degrading activity in the genus Phanerochaete

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Abstract

As white-rot basidiomycetes, Phanerochaete species are critical to the cycling of carbon sequestered as woody biomass, and are predicted to encode many enzymes that can be harnessed to promote the conversion of lignocellulose to sugars for fermentation to fuels and chemicals. Advances in genomic, transcriptomic, and proteomic technologies have enabled detailed analyses of different Phanerochaete species and have revealed numerous enzyme families required for lignocellulose utilization, as well as insight into the regulation of corresponding genes. Recent studies of Phanerochaete are also exemplified by molecular analyses following cultivation on different wood preparations, and show substrate-dependent responses that were difficult to predict using model compounds or isolated plant polysaccharides. The aim of this mini-review is to synthesize results from studies that have applied recent advances in molecular tools to evaluate the expression and regulation of proteins that contribute to lignocellulose conversion in Phanerochaete species. The identification of proteins with as yet unknown function are also highlighted and noted as important targets for future investigation of white-rot decay.

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Acknowledgments

J. MacDonald and H. Suzuki were supported by grants from the Natural Sciences and Engineering Research Council to E.R.M. We thank Mr. A. Nakamura (University of Tokyo) for sharing his insight into Phanerochaete strain history.

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  1. Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario, M5S 3E5, Canada

    Jacqueline MacDonald, Hitoshi Suzuki & Emma R. Master

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  1. Jacqueline MacDonald
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MacDonald, J., Suzuki, H. & Master, E.R. Expression and regulation of genes encoding lignocellulose-degrading activity in the genus Phanerochaete . Appl Microbiol Biotechnol 94, 339–351 (2012). https://doi.org/10.1007/s00253-012-3937-z

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