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Global physiological understanding and metabolic engineering of microorganisms based on omics studies

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Abstract

Through metabolic engineering, scientists seek to modify the metabolic pathways of living organisms to facilitate optimized, efficient production of target biomolecules. During the past decade, we have seen notable improvements in biotechnology, many of which have been based on metabolically engineered microorganisms. Recent developments in the fields of functional genomics, transcriptomics, proteomics, and metabolomics have changed metabolic engineering strategies from the local pathway level to the whole system level. This article focuses on recent advances in the field of metabolic engineering, which have been powered by the combined approaches of the various “omics” that allow us to understand the microbial metabolism at a global scale and to develop more effectively redesigned metabolic pathways for the enhanced production of target bioproducts.

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Acknowledgements

Our work described in this paper was supported by the Korean Systems Biology Research Program (M10309020000-03B5002-00000) of the Ministry of Science and Technology and by the BK21 project. Further supports by LG Chem Chair Professorship, KOSEF through the CUPS, Microsoft, and IBM-SUR program are greatly appreciated.

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  1. Corporate R&D, LG Chem, Ltd./Research Park, 104-1 Moonji-dong, Yuseong-gu, Daejeon, 305-380, Republic of Korea

    S. J. Park & J. Cho

  2. Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical & Biomolecular Engineering and BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon, 305-701, Republic of Korea

    S. Y. Lee, T. Y. Kim, J. W. Lee, J. H. Park & M.-J. Han

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  1. S. J. Park
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Park, S.J., Lee, S.Y., Cho, J. et al. Global physiological understanding and metabolic engineering of microorganisms based on omics studies. Appl Microbiol Biotechnol 68, 567–579 (2005). https://doi.org/10.1007/s00253-005-0081-z

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