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Micro total analysis system (μ-TAS) in biotechnology

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Abstract

Nanobiotechnology raises fascinating possibilities for new analytical assays in various fields such as bioelectronic assembly, biomechanics and sampling techniques, as well as in chips or micromachined devices. Recently, nanotechnology has greatly impacted biotechnological research with its potential applications in smart devices that can operate at the level of molecular manipulation. Micro total analysis system (μ-TAS) offers the potential for highly efficient, simultaneous analysis of a large number of biologically important molecules in genomic, proteomic and metabolic studies. This review aims to describe the present state-of-the-art of microsystems for use in biotechnological research, medicine and diagnostics.

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Acknowledgements

This review was made possible by the support from the Center for Ultramicrochemical Process Systems sponsored by KOSEF, National Research Laboratory Program (2000-N-NL-01-C-237) of the Ministry of Science and Technology, the Advanced Backbone IT Technology Development Project (IMT2000-B3–2) of the Ministry of Information and Communication (MIC), and BK21 project.

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  1. Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, BioProcess Engineering Research Center and Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, 373–1 Guseong-dong, Yuseong-gu, 305–701, Daejeon, Korea

    S. J. Lee & S. Y. Lee

  2. Department of Biosystems and Bioinformatics Research Center, Korea Advanced Institute of Science and Technology, 373–1 Guseong-dong, Yuseong-gu, 305–701, Daejeon, Korea

    S. Y. Lee

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Lee, S.J., Lee, S.Y. Micro total analysis system (μ-TAS) in biotechnology. Appl Microbiol Biotechnol 64, 289–299 (2004). https://doi.org/10.1007/s00253-003-1515-0

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