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Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species

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A Correction to this article was published on 19 November 2019

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Abstract

The major histocompatibility complex (MHC) is central to the innate and adaptive immune responses of jawed vertebrates. Characteristic of the MHC are high gene density, gene copy number variation, and allelic polymorphism. Because apes and monkeys are the closest living relatives of humans, the MHCs of these non-human primates (NHP) are studied in depth in the context of evolution, biomedicine, and conservation biology. The Immuno Polymorphism Database (IPD)-MHC NHP Database (IPD-MHC NHP), which curates MHC data of great and small apes, as well as Old and New World monkeys, has been upgraded. The curators of the database are responsible for providing official designations for newly discovered alleles. This nomenclature report updates the 2012 report, and summarizes important nomenclature issues and relevant novel features of the IPD-MHC NHP Database.

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Change history

  • 19 November 2019

    The original version of this article contained a spelling error in the Acknowledgments regarding the name of the funding organisation supporting GM and JAH. UKRI-BBSCR should have been UKRI-BBSRC, as is now indicated correctly below.

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Acknowledgments

The authors would like to thank R. Wiseman and J. Caskey for their feedback on the manuscript, D. Devine for editing the manuscript, and F. van Hassel for the artwork. This study was supported in part by NIH/NIAID contract number HHSN272201600007C. GM and JAH are supported by the funding from the UKRI-BBSCR awards BB/M011488/1, BBS/E/I/00001710, BBS/E/I/00007030, and BBS/E/I/00007038.

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Author notes

  1. Natasja G. de Groot and Nel Otting contributed equally to this work.

Authors and Affiliations

  1. Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ, Rijswijk, The Netherlands

    Natasja G. de Groot, Nel Otting & Ronald E. Bontrop

  2. The Pirbright Institute, Pirbright, Woking, Surrey, UK

    Giuseppe Maccari & John A. Hammond

  3. Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London, NW3 2QG, UK

    Giuseppe Maccari, James Robinson & Steven G. E. Marsh

  4. UCL Cancer Institute, University College London, Royal Free Campus, Pond Street, Hampstead, London, NW3 2QG, UK

    James Robinson & Steven G. E. Marsh

  5. Centre de Physiopathologie Toulouse-Purpan (CPTP), Université de Toulouse, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (Inserm), Université Paul Sabatier (UPS), 31000, Toulouse, France

    Antoine Blancher

  6. Laboratoire d’Immunologie, CHU de Toulouse, Institut Fédératif de Biologie, Hôpital Purpan, 330 Avenue de Grande Bretagne, TSA40031, 31059, Toulouse CEDEX 9, France

    Antoine Blancher

  7. Viral Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA

    Bernard A. P. Lafont

  8. Department of Structural Biology and Department of Microbiology and Immunology, Stanford University, Stanford, CA, 94305, USA

    Lisbeth A. Guethlein & Peter Parham

  9. Department of Anthropology, Washington University, St Louis, MO, 63130, USA

    Emily E. Wroblewski

  10. Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Hiratsuka-shi, Kanagawa, Japan

    Takashi Shiina

  11. Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, 37077, Göttingen, Germany

    Lutz Walter

  12. Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany

    Linda Vigilant

  13. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, 53711, USA

    David H. O’Connor

  14. Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH, Utrecht, The Netherlands

    Ronald E. Bontrop

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  1. Natasja G. de Groot
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  2. Nel Otting
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Correspondence to Natasja G. de Groot.

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This article is part of the Topical Collection on “Nomenclature, databases and bioinformatics in Immunogenetics”

Natasja G. de Groot, Nel Otting, and Ronald E. Bontrop are curators of the IPD-MHC NHP database.

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de Groot, N.G., Otting, N., Maccari, G. et al. Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species. Immunogenetics 72, 25–36 (2020). https://doi.org/10.1007/s00251-019-01132-x

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