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Interleukin-18 gene polymorphism, but not interleukin-2 gene polymorphism, is associated with rheumatoid arthritis

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Abstract

To investigate whether polymorphisms of IL-2 and IL-18 genes are associated with rheumatoid arthritis (RA), polymorphisms of IL-2 and IL-18 genes were detected by polymerase-chain-reaction-based restriction analysis in the patients with RA and normal controls. The results for the IL-18 gene revealed a significant difference between the patients and the normal controls (p = 0.000003), but there was no significant difference for the IL-2 gene (p = 0.876). The IL-18 gene 105A allele was associated with RA in Chinese patients. Individuals possessing the 105A allele had a higher incidence of RA. A lack of association of IL-2 gene polymorphism between RA patients and healthy individuals was noted. The results of this study provide genetic evidence that IL-18-105A/C polymorphism may play an effective role in RA.

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Acknowledgment

We thank Dr. Kuang Fu Cheng at China University Medical Biostatistics Center for suggestions. This work was supported by grant DMR-91-005 from Department of Medical Research, China Medical University Hospital, grant CMU95-132 from China Medical University and the National Science Council in Taiwan. C.-C. Lee and W.-Y. Lin contributed equally to this work.

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Authors and Affiliations

  1. Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, Taichung, Taiwan

    Cheng-Chun Lee, Wei-Yong Lin, Lei Wan, Ying-Ju Lin, Chang-Hai Tsai & Fuu-Jen Tsai

  2. Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan

    Wei-Yong Lin

  3. Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan

    Lei Wan & Yuhsin Tsai

  4. Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan

    Lei Wan, Chang-Hai Tsai & Fuu-Jen Tsai

  5. Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan

    Ying-Ju Lin

  6. Division of Immunology and Rheumatology, China Medical University Hospital, Taichung, Taiwan

    Chung-Ming Huang

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  1. Cheng-Chun Lee
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Lee, CC., Lin, WY., Wan, L. et al. Interleukin-18 gene polymorphism, but not interleukin-2 gene polymorphism, is associated with rheumatoid arthritis. Immunogenetics 59, 433–439 (2007). https://doi.org/10.1007/s00251-007-0212-z

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  • DOI: https://doi.org/10.1007/s00251-007-0212-z

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