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Association of TAP2 gene polymorphisms in Chinese patients with rheumatoid arthritis

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Abstract

The aim of this study was to investigate the association between the polymorphism of transporters associated with antigen processing (TAP1/TAP2) genes and rheumatoid arthritis in Chinese patients. A total of 100 RA patients and 99 healthy control subjects were enrolled. Analyses with polymerase chain reaction (PCR) based restrictions were used to identify the polymorphisms of the TAP1 and TAP2 genes, which were mapped on chromosome 6. There was a significant difference in the distribution of the TAP2 gene codon 565 polymorphism frequency between the RA patients and healthy control subjects (p<0.001). The odds ratio for the risk of the ‘A’ allele in RA patients was 1.60 (95% CI: 0.82–2.92). No statistical associations in the distribution of the TAP1 gene polymorphism frequency were found between RA patients and controls. There were some physical links found between TAP1/TAP2 gene polymorphism loci. However, there was no linkage observed from TAP1/TAP2 gene polymorphisms and HLA-DRB1*04 between RA patients and healthy controls. We concluded that the TAP2 gene codon 565 ‘A’ allele was associated with RA in Chinese patients in Taiwan. Individuals possessing the ‘A’ allele had a higher incidence of RA. A lack of association of TAP1 gene polymorphisms between RA patients and healthy individuals was noted. The results of this study provide genetic evidence that TAP2 gene codon 565 polymorphism may play a role in RA.

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Abbreviations

MHC:

Major histocompatibility

MS:

Multiple sclerosis

PCR:

Polymerase chain reaction

RA:

Rheumatoid arthritis

SNP:

Single nucleotide polymorphism

References

  1. Krane SM, Simon LS (1986) Rheumatoid arthritis: clinical features and pathogenetic mechanisms. Med Clin North Am 70:263–284

    CAS  PubMed  Google Scholar 

  2. Panayi GTS, Lanchbury JS, Kingsley GH (1992) The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum 35:729–735

    Google Scholar 

  3. Moreland LW, Heck LW, Sullivan W, Pratt PW, Koopman WJ (1993) New approaches to the therapy of autoimmune diseases: Rheumatoid arthritis as a paradigm. Am J Med Sci 305:40–51

    CAS  PubMed  Google Scholar 

  4. Wagner U, Kaltenhauser S, Sauer H et al. (1997) HLA markers and prediction of clinical course and outcome in rheumatoid arthritis. Arthritis Rheum 40:341–351

    CAS  PubMed  Google Scholar 

  5. Van Zeben D, Hazes JMW, Zwinderman AH et al. (1991) Association of HLA-DR4 with a more progressive disease course in patients with rheumatoid arthritis: results of a followup study. Arthritis Rheum 34:822–830

    PubMed  Google Scholar 

  6. Gregerson P, Silver J, Winchester R (1987) The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 30:1205–1213

    CAS  PubMed  Google Scholar 

  7. Ziegler A, Field LL, Sakaguchi AY (1991) Report of the committee on the genetic constitution of chromosome 6. Cytogenet Cell Genet 295–336

  8. Kelly A, Powis SH, Glynne R, Radley E, Beck S, Trowsdale J (1990) A proteasome-related gene between the ABC transporter loci in the class II region of the human MHC. Nature 353:357–360

    Google Scholar 

  9. Powis SH, Mockridge I, Kelly A et al. (1992) Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex. Proc Natl Acad Sci USA 89:1463–1467

    CAS  PubMed  Google Scholar 

  10. Colonna M, Bresnahan M, Bahram S, Strominger JL, Spies T (1992) Allelic variants of the human putative peptide transporter involved in antigen processing. Proc Natl Acad Sci USA 89:3932–3936

    CAS  PubMed  Google Scholar 

  11. Aoki Y, Isselbacher KJ, Pillai S (1993) Polymorphisms involving the transmembrane domains of human TAP 2. Immunogenetics 38:382

    CAS  PubMed  Google Scholar 

  12. Huang CM, Wu MC, Wu JY, Tsai FJ (2002) Association of vitamin-D receptor gene Bsm I polymorphisms in Chinese patients with systemic lupus erythematosus. Lupus 11:31–34

    Article  CAS  PubMed  Google Scholar 

  13. Huang CM, Wu MC, Wu JY, Tsai FJ (2002) No association of vitamin-D receptor gene start condon Fok I polymorphisms in Chinese patients with systemic lupus erythematosus. J Rheumatol 29:1121–1123

    PubMed  Google Scholar 

  14. Kuwata S, Yanagisawa M, Saeki H et al. (1995) Lack of primary association between transporter associated with antigen processing genes and atopic dermatitis. J Allergy Clin Immunol 96:1051–1060

    CAS  Google Scholar 

  15. Arnett FC, Edworthy SM, Bloch DA et al. (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 3:315–324

    Google Scholar 

  16. Monaco JJ (1992) A molecular model of MHC class I restricted antigen processing. Immunol Today 13:173–179

    Article  CAS  PubMed  Google Scholar 

  17. Hayashi T, Morimoto C, Burks JS, Kerr C, Hauser SL (1988) Dual-label immunocytochemistry of the active multiple sclerosis lesion: major histocompatibility complex and activation antigens. Ann Neurol 24:523–531

    CAS  PubMed  Google Scholar 

  18. Faustmann DL (1993) Mechanisms of autoimmunity in type I diabetes. J Clin Immunol 47:3–10

    Google Scholar 

  19. Powis SJ, Deverson EV, Coadwell WJ (1992) Effect of polymorphism of an MHC-linked transporter on the peptides assembles in a class I molecule. Nature 357:211–215

    CAS  PubMed  Google Scholar 

  20. Momburg F, Roelse J, Hammerling GJ (1994) Peptide size selection by the major histocompatibility complex-encoded peptide transporter. J Exp Med 179:1613–1623

    CAS  PubMed  Google Scholar 

  21. Huang CM, Wu MC, Wu JY, Tsai FJ (2002) Lack of association of interleukin-1β gene polymorphisms in Chinese patients with systemic lupus erythematosus. Rheumatol Int 21:173–175

    Article  CAS  PubMed  Google Scholar 

  22. Mathew C (2001) Postgenomic technologies: hunting the genes for common disorders. Br Med J 322:1031–1034

    Article  CAS  Google Scholar 

  23. Wordsworth BP, Pile KD, Gibson K, Burney RO, Mockridge I, Powis SH (1993) Analysis of the MHC-encoded transporters TAP1 and TAP2 in rheumatoid arthritis: linkage with DR4 accounts for the association with a minor TAP2 allele. Tissue Antigens 42:153–155

    CAS  PubMed  Google Scholar 

  24. Vandevyver C, Geusens P, cassiman J-J, Raus J (1995) Peptide transporter genes (TAP) polymorphisms and genetic susceptibility to rheumatoid arthritis. Br J Rheumatol 34:207–214

    CAS  PubMed  Google Scholar 

  25. Olerup O. Zetterquist H (1992) HLA-DR typing by PCR amplification with sequenc-specific primers (PCR-SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 39: 225–235

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. China Medical College Hospital, No 2 Yuh Der Road, Taichung, Taiwan

    Min-Chien Yu, Chung-Ming Huang, Mei-Chen Wu, Jer-Yuarn Wu & Fuu-Jen Tsai

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  1. Min-Chien Yu
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  2. Chung-Ming Huang
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  3. Mei-Chen Wu
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  4. Jer-Yuarn Wu
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  5. Fuu-Jen Tsai
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Correspondence to Fuu-Jen Tsai.

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Yu, MC., Huang, CM., Wu, MC. et al. Association of TAP2 gene polymorphisms in Chinese patients with rheumatoid arthritis. Clin Rheumatol 23, 35–39 (2004). https://doi.org/10.1007/s10067-003-0769-3

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