Abstract
By determining the nucleotide sequences of more than 700 cDNA clones isolated from 16 cynomolgus monkeys, we identified 26 Mafa-B alleles. In addition, nine sequences with similarity to Mamu-I alleles were identified. Since multiple Mafa-B alleles were found in each individual, it was strongly suggested that the cynomolgus MHC class I B locus might be duplicated and that the Mafa-I locus was derived from the B locus by gene duplication, as in the case of the Mamu-I locus of rhesus monkeys.
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Acknowledgements
We thank K. Ono, A. Hiyaoka, M, Maeshima, and other staff in The Corporation of Production and Breeding of Primate for animal care and blood collection. This study was supported by the Program of Fundamental Studies in Health Science of the Organization for Pharmaceutical Safety and Research of Japan, and by the Health Science Research Grants from the Ministry of Health and Welfare of Japan.
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Uda, A., Tanabayashi, K., Fujita, O. et al. Identification of the MHC class I B locus in cynomolgus monkeys. Immunogenetics 57, 189–197 (2005). https://doi.org/10.1007/s00251-005-0782-6
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DOI: https://doi.org/10.1007/s00251-005-0782-6