Abstract
Homer proteins have recently been identified as novel high-affinity ligands that modulate ryanodine receptor (RyR) Ca2+ release channels in heart and skeletal muscle, through an EVH1 domain which binds to proline-rich regions in target proteins. Many Homer proteins can also self-associate through a coiled-coil domain that allows their multimerisation. In other tissues, especially neurons, Homer anchors proteins embedded in the surface membrane to the Ca2+ release channel in the endoplasmic reticulum and can anchor membrane or cytosolic proteins to the cytoskeleton. Although this anchoring aspect of Homer function has not been extensively investigated in muscle, there are consensus sequences for Homer binding in the RyR and on many of the proteins that it interacts with in the massive RyR ion channel complex. In this review we explore the potential of Homer to contribute to a variety of cell processes in muscle and neurons that also involve RyR channels.
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References
Ajima R, Kajiya K, Inoue T et al (2007) HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth. Biochem Biophys Res Commun 356:851–856. doi:10.1016/j.bbrc.2007.03.060
Albert AP, Saleh SN, Peppiatt-Wildman CM et al (2007) Multiple activation mechanisms of store-operated TRPC channels in smooth muscle cells. J Physiol 583:25–36. doi:10.1113/jphysiol.2007.137802
Barzik M, Carl UD, Schubert WD et al (2001) The N-terminal domain of Homer/Vesl is a new class II EVH1 domain. J Mol Biol 309:155–169. doi:10.1006/jmbi.2001.4640
Bauman AL, Michel JJ, Henson E et al (2007) The mAKAP signalosome and cardiac myocyte hypertrophy. IUBMB Life 59:163–169. doi:10.1080/15216540701358593
Beneken J, Tu JC, Xiao B et al (2000) Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron 26:143–154. doi:10.1016/S0896-6273(00)81145-9
Beri S, Tonna N, Menozzi G et al (2007) DNA methylation regulates tissue-specific expression of Shank3. J Neurochem 101:1380–1391. doi:10.1111/j.1471-4159.2007.04539.x
Beutner G, Sharma VK, Giovannucci DR et al (2001) Identification of a ryanodine receptor in rat heart mitochondria. J Biol Chem 276:21482–21488. doi:10.1074/jbc.M101486200
Bhat MB, Ma J (2002) The transmembrane segment of ryanodine receptor contains an intracellular membrane retention signal for Ca2+ release channel. J Biol Chem 277:8597–8601. doi:10.1074/jbc.M107609200
Boeckers TM, Bockmann J, Kreutz MR et al (2002) ProSAP/Shank proteins—a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease. J Neurochem 81:903–910. doi:10.1046/j.1471-4159.2002.00931.x
Bortoloso E, Pilati N, Megighian A et al (2006) Transition of Homer isoforms during skeletal muscle regeneration. Am J Physiol Cell Physiol 290:C711–C718. doi:10.1152/ajpcell.00217.2005
Brakeman PR, Lanahan AA, O’Brien R et al (1997) Homer: a protein that selectively binds metabotropic glutamate receptors. Nature 386:284–288. doi:10.1038/386284a0
Bultynck G, Vermassen E, Szlufcik K et al (2003) Calcineurin and intracellular Ca2+-release channels: regulation or association? Biochem Biophys Res Commun 311:1181–1193. doi:10.1016/j.bbrc.2003.08.084
Chavis P, Fagni L, Lansman JB et al (1996) Functional coupling between ryanodine receptors and L-type calcium channels in neurons. Nature 382:719–722. doi:10.1038/382719a0
Cifuentes F, Gonzalez CE, Fiordelisio T et al (2001) A ryanodine fluorescent derivative reveals the presence of high-affinity ryanodine binding sites in the Golgi complex of rat sympathetic neurons, with possible functional roles in intracellular Ca2+ signaling. Cell Signal 13:353–362. doi:10.1016/S0898-6568(01)00132-2
Copello JA, Zima AV, Diaz-Sylvester PL et al (2007) Ca2+ entry-independent effects of L-type Ca2+ channel modulators on Ca2+ sparks in ventricular myocytes. Am J Physiol Cell Physiol 292:C2129–C2140. doi:10.1152/ajpcell.00437.2006
Currie S, Loughrey CM, Craig MA et al (2004) Calcium/calmodulin-dependent protein kinase IIdelta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochem J 377:357–366. doi:10.1042/BJ20031043
Dammermann W, Guse AH (2005) Functional ryanodine receptor expression is required for NAADP-mediated local Ca2+ signaling in T-lymphocytes. J Biol Chem 280:21394–21399. doi:10.1074/jbc.M413085200
Dan P, Lin E, Huang J et al (2007) Three-dimensional distribution of cardiac Na+–Ca2+ exchanger and ryanodine receptor during development. Biophys J 93:2504–2518. doi:10.1529/biophysj.107.104943
De Crescenzo V, Fogarty KE, Zhuge R et al (2006) Dihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals. J Neurosci 26:7565–7574. doi:10.1523/JNEUROSCI.1512-06.2006
Diagana TT, Thomas U, Prokopenko SN et al (2002) Mutation of Drosophila homer disrupts control of locomotor activity and behavioral plasticity. J Neurosci 22:428–436
Diaz-Munoz M, Hamilton SL, Kaetzel MA et al (1990) Modulation of Ca2+ release channel activity from sarcoplasmic reticulum by annexin VI (67-kDa calcimedin). J Biol Chem 265:15894–15899
Du W, McMahon TJ, Zhang ZS et al (2006) Excitation-contraction coupling in airway smooth muscle. J Biol Chem 281:30143–30151. doi:10.1074/jbc.M606541200
Ducreux S, Zorzato F, Ferreiro A et al (2006) Functional properties of ryanodine receptors carrying three amino acid substitutions identified in patients affected by multi-minicore disease and central core disease, expressed in immortalized lymphocytes. Biochem J 395:259–266. doi:10.1042/BJ20051282
Dulhunty AF, Haarmann CS, Green D et al (2002) Interactions between dihydropyridine receptors and ryanodine receptors in striated muscle. Prog Biophys Mol Biol 79:45–75. doi:10.1016/S0079-6107(02)00013-5
Duncan RS, Hwang SY, Koulen P (2005) Effects of Vesl/Homer proteins on intracellular signaling. Exp Biol Med (Maywood) 230:527–535
Fagni L, Worley PF, Ango F (2002) Homer as both a scaffold and transduction molecule. Sci STKE 137:RE8. doi:10.1126/stke.2002.137.re8
Felder E, Franzini-Armstrong C (2002) Type 3 ryanodine receptors of skeletal muscle are segregated in a parajunctional position. Proc Natl Acad Sci USA 99:1695–1700. doi:10.1073/pnas.032657599
Feng W, Tu J, Yang T et al (2002) Homer regulates gain of ryanodine receptor type 1 channel complex. J Biol Chem 277:44722–44730. doi:10.1074/jbc.M207675200
Feng W, Tu J, Pouliquin P et al (2008) Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1. Cell Calcium 43:307–314. doi:10.1016/j.ceca.2007.06.001
Fill M, Copello JA (2002) Ryanodine receptor calcium release channels. Physiol Rev 82:893–922
Fraser ID, Scott JD (1999) Modulation of ion channels: a “current” view of AKAPs. Neuron 23:423–426. doi:10.1016/S0896-6273(00)80795-3
Gao L, Tripathy A, Lu X et al (1997) Evidence for a role of C-terminal amino acid residues in skeletal muscle Ca2+ release channel (ryanodine receptor) function. FEBS Lett 412:223–226. doi:10.1016/S0014-5793(97)00781-3
George CH, Rogers SA, Bertrand BM et al (2007) Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signaling and susceptibility to apoptosis. Circ Res 100:874–883. doi:10.1161/01.RES.0000260804.77807.cf
Gerasimenko JV, Maruyama Y, Yano K et al (2003) NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. J Cell Biol 163:271–282. doi:10.1083/jcb.200306134
Giannini G, Conti A, Mammarella S et al (1995) The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues. J Cell Biol 128:893–904. doi:10.1083/jcb.128.5.893
Guatimosim S, Amaya MJ, Guerra MT et al (2008) Nuclear Ca2+ regulates cardiomyocyte function. Cell Calcium 44:230–242. doi:10.1016/j.ceca.2007.11.016
Hosoi E, Nishizaki C, Gallagher KL et al (2001) Expression of the ryanodine receptor isoforms in immune cells. J Immunol 167:4887–4894
Huang G, Kim JY, Dehoff M et al (2007) Ca2+ signaling in microdomains: Homer1 mediates the interaction between RyR2 and Cav1.2 to regulate excitation-contraction coupling. J Biol Chem 282:14283–14290. doi:10.1074/jbc.M611529200
Huang GN, Huso DL, Bouyain S et al (2008) NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science 319:476–481. doi:10.1126/science.1151227
Hwang SY, Wei J, Westhoff JH et al (2003) Differential functional interaction of two Vesl/Homer protein isoforms with ryanodine receptor type 1: a novel mechanism for control of intracellular calcium signaling. Cell Calcium 34:177–184. doi:10.1016/S0143-4160(03)00082-4
Inoue Y, Honkura N, Kato A et al (2004) Activity-inducible protein Homer1a/Vesl-1S promotes redistribution of postsynaptic protein Homer1c/Vesl-1L in cultured rat hippocampal neurons. Neurosci Lett 354:143–147. doi:10.1016/j.neulet.2003.09.082
Kapiloff MS (2002) Contributions of protein kinase A anchoring proteins to compartmentation of cAMP signaling in the heart. Mol Pharmacol 62:193–199. doi:10.1124/mol.62.2.193
Kato A, Ozawa F, Saitoh Y et al (1997) vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis. FEBS Lett 412:183–189. doi:10.1016/S0014-5793(97)00775-8
Kawamoto T, Togi K, Yamauchi R et al (2006) Endothelin-1 activates Homer 1alpha expression via mitogen-activated protein kinase in cardiac myocytes. Int J Mol Med 18:193–196
Kim S, Yun HM, Baik JH et al (2007) Functional interaction of neuronal Cav1.3 L-type calcium channel with ryanodine receptor type 2 in the rat hippocampus. J Biol Chem 282:32877–32889. doi:10.1074/jbc.M701418200
Kiselyov KI, Shin DM, Wang Y et al (2000) Gating of store-operated channels by conformational coupling to ryanodine receptors. Mol Cell 6:421–431. doi:10.1016/S1097-2765(00)00041-1
Kramerova I, Kudryashova E, Wu B et al (2008) Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle. Hum Mol Genet 17:3271–3280. doi:10.1093/hmg/ddn223
Lai MM, Burnett PE, Wolosker H et al (1998) Cain, a novel physiologic protein inhibitor of calcineurin. J Biol Chem 273:18325–18331. doi:10.1074/jbc.273.29.18325
Lee M, Park J (2006) Regulation of NFAT activation: a potential therapeutic target for immunosuppression. Mol Cells 22:1–7. doi:10.1016/j.molcel.2006.03.017
Lee EH, Cherednichenko G, Pessah IN et al (2006a) Functional coupling between TRPC3 and RyR1 regulates the expressions of key triadic proteins. J Biol Chem 281:10042–10048. doi:10.1074/jbc.M600981200
Lee EH, do Kim H, Allen PD (2006b) Interplay between intra- and extracellular calcium ions. Mol Cells 21:315–329
Levitan ES (2008) Signaling for vesicle mobilization and synaptic plasticity. Mol Neurobiol 37:39–43. doi:10.1007/s12035-008-8014-3
MacKrill JJ (1999) Protein–protein interactions in intracellular Ca2+-release channel function. Biochem J 337(Pt 3):345–361. doi:10.1042/0264-6021:3370345
Marx SO, Reiken S, Hisamatsu Y et al (2000) PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101:365–376. doi:10.1016/S0092-8674(00)80847-8
Meur G, Parker AK, Gergely FV et al (2007) Targeting and retention of type 1 ryanodine receptors to the endoplasmic reticulum. J Biol Chem 282:23096–23103. doi:10.1074/jbc.M702457200
Mitchell KJ, Pinton P, Varadi A et al (2001) Dense core secretory vesicles revealed as a dynamic Ca(2+) store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera. J Cell Biol 155:41–51. doi:10.1083/jcb.200103145
Mizutani A, Kuroda Y, Futatsugi A et al (2008) Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. J Neurosci 28:5369–5382. doi:10.1523/JNEUROSCI.4738-07.2008
Mohler PJ, Gramolini AO, Bennett V (2002) The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1, 4, 5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. J Biol Chem 277:10599–10607. doi:10.1074/jbc.M110958200
Mouton J, Marty I, Villaz M et al (2001) Molecular interaction of dihydropyridine receptors with type-1 ryanodine receptors in rat brain. Biochem J 354:597–603. doi:10.1042/0264-6021:3540597
Obermair GJ, Tuluc P, Flucher BE (2008) Auxiliary Ca(2+) channel subunits: lessons learned from muscle. Curr Opin Pharmacol 8:311–318. doi:10.1016/j.coph.2008.01.008
Okabe S, Urushido T, Konno D et al (2001) Rapid redistribution of the postsynaptic density protein PSD-Zip45 (Homer 1c) and its differential regulation by NMDA receptors and calcium channels. J Neurosci 21:9561–9571
Ono Y, Shimada H, Sorimachi H et al (1998) Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A. J Biol Chem 273:17073–17078. doi:10.1074/jbc.273.27.17073
Ouardouz M, Nikolaeva MA, Coderre E et al (2003) Depolarization-induced Ca2+ release in ischemic spinal cord white matter involves L-type Ca2+ channel activation of ryanodine receptors. Neuron 40:53–63. doi:10.1016/j.neuron.2003.08.016
Pan Z, Yang D, Nagaraj RY et al (2002) Dysfunction of store-operated calcium channel in muscle cells lacking mg29. Nat Cell Biol 4:379–383. doi:10.1038/ncb788
Pawson T, Nash P (2003) Assembly of cell regulatory systems through protein interaction domains. Science 300:445–452. doi:10.1126/science.1083653
Pouliquin P, Pace SM, Curtis SM et al (2006) Effects of an alpha-helical ryanodine receptor C-terminal tail peptide on ryanodine receptor activity: modulation by Homer. Int J Biochem Cell Biol 38:1700–1715. doi:10.1016/j.biocel.2006.03.020
Pouliquin P, Pace SM, Dulhunty AF (2009) In vitro modulation of the cardiac ryanodine receptor activity by Homer1. Pfluggers Arch (in press). doi:10.1007/s00424-009-0664-0
Protasi F, Franzini-Armstrong C, Allen PD (1998) Role of ryanodine receptors in the assembly of calcium release units in skeletal muscle. J Cell Biol 140:831–842. doi:10.1083/jcb.140.4.831
Rizzuto R (2001) Intracellular Ca(2+) pools in neuronal signalling. Curr Opin Neurobiol 11:306–311. doi:10.1016/S0959-4388(00)00212-9
Rossi D, Barone V, Giacomello E et al (2008) The sarcoplasmic reticulum: an organized patchwork of specialized domains. Traffic 9:1044–1049. doi:10.1111/j.1600-0854.2008.00717.x
Saito H, Kimura M, Inanobe A et al (2002) An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group I metabotropic glutamate receptor in mammalian cells. Biochem Biophys Res Commun 296:523–529. doi:10.1016/S0006-291X(02)00899-9
Salanova M, Priori G, Barone V et al (2002) Homer proteins and InsP(3) receptors co-localise in the longitudinal sarcoplasmic reticulum of skeletal muscle fibres. Cell Calcium 32:193–200. doi:10.1016/S0143416002001549
Sampieri A, Diaz-Munoz M, Antaramian A et al (2005) The foot structure from the type 1 ryanodine receptor is required for functional coupling to store-operated channels. J Biol Chem 280:24804–24815. doi:10.1074/jbc.M501487200
Sandona D, Scolari A, Mikoshiba K et al (2003) Subcellular distribution of Homer 1b/c in relation to endoplasmic reticulum and plasma membrane proteins in Purkinje neurons. Neurochem Res 28:1151–1158. doi:10.1023/A:1024264025401
Schredelseker J, Di Biase V, Obermair GJ et al (2005) The beta 1a subunit is essential for the assembly of dihydropyridine-receptor arrays in skeletal muscle. Proc Natl Acad Sci USA 102:17219–17224. doi:10.1073/pnas.0508710102
Shakiryanova D, Tully A, Hewes RS et al (2005) Activity-dependent liberation of synaptic neuropeptide vesicles. Nat Neurosci 8:173–178. doi:10.1038/nn1377
Sheng M, Kim E (2000) The Shank family of scaffold proteins. J Cell Sci 113(Pt 11):1851–1856
Shin DW, Pan Z, Bandyopadhyay A et al (2002) Ca(2+)-dependent interaction between FKBP12 and calcineurin regulates activity of the Ca(2+) release channel in skeletal muscle. Biophys J 83:2539–2549. doi:10.1016/S0006-3495(02)75265-X
Shiraishi Y, Mizutani A, Yuasa S et al (2004) Differential expression of Homer family proteins in the developing mouse brain. J Comp Neurol 473:582–599. doi:10.1002/cne.20116
Shiraishi-Yamaguchi Y, Furuichi T (2007) The Homer family proteins. Genome Biol 8:206. doi:10.1186/gb-2007-8-2-206
Soloviev MM, Ciruela F, Chan WY et al (2000) Mouse brain and muscle tissues constitutively express high levels of Homer proteins. Eur J Biochem 267:634–639. doi:10.1046/j.1432-1327.2000.01078.x
Stewart R, Zissimopoulos S, Lai FA (2003) Oligomerization of the cardiac ryanodine receptor C-terminal tail. Biochem J 376:795–799. doi:10.1042/BJ20030597
Stiber JA, Tabatabaei N, Hawkins AF et al (2005) Homer modulates NFAT-dependent signaling during muscle differentiation. Dev Biol 287:213–224. doi:10.1016/j.ydbio.2005.06.030
Stiber JA, Zhang ZS, Burch J et al (2008) Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. Mol Cell Biol 28:2637–2647. doi:10.1128/MCB.01601-07
Sun J, Tadokoro S, Imanaka T et al (1998) Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain. FEBS Lett 437:304–308. doi:10.1016/S0014-5793(98)01256-3
Szumlinski KK, Dehoff MH, Kang SH et al (2004) Homer proteins regulate sensitivity to cocaine. Neuron 43:401–413. doi:10.1016/j.neuron.2004.07.019
Takekura H, Flucher BE, Franzini-Armstrong C (2001) Sequential docking, molecular differentiation, and positioning of T-tubule/SR junctions in developing mouse skeletal muscle. Dev Biol 239:204–214. doi:10.1006/dbio.2001.0437
Tu JC, Xiao B, Yuan JP et al (1998) Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21:717–726. doi:10.1016/S0896-6273(00)80589-9
Valdes JA, Gaggero E, Hidalgo J et al (2008) NFAT activation by membrane potential follows a calcium pathway distinct from other activity-related transcription factors in skeletal muscle cells. Am J Physiol Cell Physiol 294:C715–C725. doi:10.1152/ajpcell.00195.2007
Vandebrouck C, Martin D, Colson-Van Schoor M et al (2002) Involvement of TRPC in the abnormal calcium influx observed in dystrophic (mdx) mouse skeletal muscle fibers. J Cell Biol 158:1089–1096. doi:10.1083/jcb.200203091
Venkatachalam K, Montell C (2007) TRP channels. Annu Rev Biochem 76:387–417. doi:10.1146/annurev.biochem.75.103004.142819
Verkhratsky A (2002) The endoplasmic reticulum and neuronal calcium signalling. Cell Calcium 32:393–404. doi:10.1016/S0143416002001896
Voeltz GK, Rolls MM, Rapoport TA (2002) Structural organization of the endoplasmic reticulum. EMBO Rep 3:944–950. doi:10.1093/embo-reports/kvf202
Ward CW, Feng W, Tu J et al (2004) Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscle. J Biol Chem 279:5781–5787. doi:10.1074/jbc.M311422200
Weerth SH, Holtzclaw LA, Russell JT (2007) Signaling proteins in raft-like microdomains are essential for Ca2+ wave propagation in glial cells. Cell Calcium 41:155–167. doi:10.1016/j.ceca.2006.06.006
Weigl L, Zidar A, Gscheidlinger R et al (2003) Store operated Ca2+ influx by selective depletion of ryanodine sensitive Ca2+ pools in primary human skeletal muscle cells. Naunyn Schmiedebergs Arch Pharmacol 367:353–363. doi:10.1007/s00210-003-0705-8
Westhoff JH, Hwang SY, Duncan RS et al (2003) Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signaling. Cell Calcium 34:261–269. doi:10.1016/S0143-4160(03)00112-X
Wong MY, Shakiryanova D, Levitan ES (2009) Presynaptic ryanodine receptor-CamKII signaling is required for activity-dependent capture of transiting vesicles. J Mol Neurosci 37:146–150
Woo JS, Kim do H, Allen PD et al (2008) TRPC3-interacting triadic proteins in skeletal muscle. Biochem J 411:399–405. doi:10.1042/BJ20071504
Worley PF, Zeng W, Huang G et al (2007) Homer proteins in Ca2+ signaling by excitable and non-excitable cells. Cell Calcium 42:363–371. doi:10.1016/j.ceca.2007.05.007
Xiao B, Tu JC, Petralia RS et al (1998) Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins. Neuron 21:707–716. doi:10.1016/S0896-6273(00)80588-7
Yin CC, D’Cruz LG, Lai FA (2008) Ryanodine receptor arrays: not just a pretty pattern? Trends Cell Biol 18:149–156. doi:10.1016/j.tcb.2008.02.003
Yuan JP, Kiselyov K, Shin DM et al (2003) Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114:777–789. doi:10.1016/S0092-8674(03)00716-5
Zaidi M, Shankar VS, Tunwell R et al (1995) A ryanodine receptor-like molecule expressed in the osteoclast plasma membrane functions in extracellular Ca2+ sensing. J Clin Invest 96:1582–1590. doi:10.1172/JCI118197
Zalk R, Lehnart SE, Marks AR (2007) Modulation of the ryanodine receptor and intracellular calcium. Annu Rev Biochem 76:367–385. doi:10.1146/annurev.biochem.76.053105.094237
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“Proteins, membranes and cells: the structure-function nexus”. Contributions from the annual scientific meeting (including a special symposium in honour of Professor Alex Hope of Flinders University, South Australia) of the Australian Society for Biophysics held in Canberra, ACT, Australia, 28 September–1 October 2008.
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Pouliquin, P., Dulhunty, A.F. Homer and the ryanodine receptor. Eur Biophys J 39, 91–102 (2009). https://doi.org/10.1007/s00249-009-0494-1
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DOI: https://doi.org/10.1007/s00249-009-0494-1