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RyR channels and glucose-regulated pancreatic β-cells

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Abstract

Ryanodine receptor channel model is introduced to a dynamical model of pancreatic β-cells to discuss the effects of RyR channels and glucose concentration on membrane potential. The results show Ca2+ concentration changes responding to enhance of glucose concentration is more quickly than that of activating RyR channels, and both methods can induce bursting action potential and increase free cytosolic Ca2+ concentration. An interesting finding is that moderate stimulation to RyR channels will result in a kind of “complex bursting”, which is more effective in enhancing average Ca2+ concentration and insulin section.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China under Grant No.10575041.

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Authors and Affiliations

  1. Department of Physics and Institute of Biophysics, Central China Normal University, 430079, Wuhan, China

    Xuan Zhan, Lijian Yang, Ming Yi & Ya Jia

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  1. Xuan Zhan
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  2. Lijian Yang
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Correspondence to Ya Jia.

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Zhan, X., Yang, L., Yi, M. et al. RyR channels and glucose-regulated pancreatic β-cells. Eur Biophys J 37, 773–782 (2008). https://doi.org/10.1007/s00249-008-0269-0

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  • DOI: https://doi.org/10.1007/s00249-008-0269-0

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