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Magnetic-resonance-guided focused ultrasound treatment of non-spinal osteoid osteoma in children: multicentre experience

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Abstract

Background

Osteoid osteoma is a benign and painful musculoskeletal tumour that usually affects children. Current standard treatment is CT-guided radiofrequency ablation, a minimally invasive percutaneous procedure, with clinical success rates ranging between 85% and 98%. Though minimally invasive, however, this type of procedure is not free from complications.

Objective

To investigate the efficacy and safety of magnetic resonance (MR)-guided focused ultrasound (MRgFUS), a needleless procedure of thermal ablation employed in the treatment of non-spinal osteoid osteoma in paediatric patients.

Materials and methods

We report the results of 33 procedures of ablation of osteoid osteoma performed with MRgFUS in three university hospitals. To ablate a lesion on the bone surface, MRgFUS employs the ultrasound energy transduced along the soft tissue. The follow-up studies lasted 24 months and were performed combining clinical and imaging data.

Results

Mean age of the children was 13.8 years. The clinical outcome showed a primary success of 97%. One case alone was submitted to repeat treatment because the first one failed (secondary success). No major or minor complications were recorded. During the investigation time, no relapse of symptomatology or delayed complications were observed.

Conclusion

Although our study is preliminary and limited by a low number of patients, our data show that MRgFUS is effective. This suggests that it might be useful as the first-line treatment in paediatric patients with osteoid osteoma.

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Acknowledgements

We thank Angela Martella for translating the manuscript.

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Authors and Affiliations

  1. Department of Emergency Radiology, San Salvatore Hospital, via Vetoio, 67100, L’Aquila, Italy

    Francesco Arrigoni & Luigi Zugaro

  2. Department of Radiologic, Oncologic and Pathologic Sciences, La Sapienza University of Rome, Rome, Italy

    Alessandro Napoli, Roberto Scipione, Michele Anzidei & Carlo Catalano

  3. Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Via G. C. Pupilli 1, 40136, Bologna, Italy

    Alberto Bazzocchi & Daniele Mercatelli

  4. Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila Via Giovanni Di Vincenzo, L’Aquila, Italy

    Federico Bruno, Pierpaolo Palumbo, Giovanni Luca Gravina, Antonio Barile & Carlo Masciocchi

  5. Oncological Orthopedics Department, Regina Elena National Cancer Institute, Rome, Italy

    Carmine Zoccali

  6. Department of Radiology, Stanford University Medical Center, Stanford, CA, USA

    Pejman Ghanouni

Authors
  1. Francesco Arrigoni
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  2. Alessandro Napoli
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  3. Alberto Bazzocchi
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  4. Luigi Zugaro
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  6. Federico Bruno
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  8. Michele Anzidei
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  9. Daniele Mercatelli
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  10. Giovanni Luca Gravina
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  11. Carmine Zoccali
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  12. Pejman Ghanouni
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  13. Antonio Barile
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  14. Carlo Catalano
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  15. Carlo Masciocchi
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Correspondence to Francesco Arrigoni.

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Arrigoni, F., Napoli, A., Bazzocchi, A. et al. Magnetic-resonance-guided focused ultrasound treatment of non-spinal osteoid osteoma in children: multicentre experience. Pediatr Radiol 49, 1209–1216 (2019). https://doi.org/10.1007/s00247-019-04426-0

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  • DOI: https://doi.org/10.1007/s00247-019-04426-0

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