Skip to main content

Advertisement

SpringerLink
Log in

Extracardiac applications of MR blood pool contrast agent in children

  • Pictorial Essay
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

Magnetic resonance (MR) angiography has significantly reduced the need for diagnostic conventional angiography and is preferred over CT angiography in children because of its lack of ionizing radiation. The availability of gadofosveset trisodium (the only clinically approved blood pool MR contrast agent) has led to an increase in applications of MR for vascular imaging and an improvement in diagnostic quality of MR angiography. Gadofosveset is a gadolinium-based contrast agent that binds reversibly to albumin, resulting in increased paramagnetic effect and longer intravascular residence. This allows for high-resolution arterial and venous MR angiography, assessment of flow characteristics of vascular malformations, dynamic vascular imaging, and multi-station imaging with a single low-dose gadolinium contrast injection. The purpose of this pictorial essay is to facilitate understanding of the kinetics and safety profile of gadofosveset trisodium, discuss technical aspects of imaging, and illustrate advantages and extracardiac applications in pediatric body imaging.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13
Fig. 14
Fig. 15
Fig. 16

References

  1. U.S. Food and Drug Administration (2010) Highlights of prescribing information: Ablavar. http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021711s003lbl.pdf. Accessed 11 Aug 2014

  2. Parmelee DJ, Walovitch RC, Ouellet HS et al (1997) Preclinical evaluation of the pharmacokinetics, biodistribution, and elimination of MS-325, a blood pool agent for magnetic resonance imaging. Invest Radiol 32:741–747

    Article  CAS  PubMed  Google Scholar 

  3. Grist TM, Korosec FR, Peters DC et al (1998) Steady-state and dynamic MR angiography with MS-325: initial experience in humans. Radiology 207:539–544

    Article  CAS  PubMed  Google Scholar 

  4. Henness S, Keating GM (2006) Gadofosveset. Drugs 66:851–857

    Article  CAS  PubMed  Google Scholar 

  5. Caravan P, Cloutier NJ, Greenfield MT et al (2002) The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates. J Am Chem Soc 124:3152–3162

    Article  CAS  PubMed  Google Scholar 

  6. Perreault P, Edelman MA, Baum RA et al (2003) MR angiography with gadofosveset trisodium for peripheral vascular disease: phase II trial. Radiology 229:811–820

    Article  PubMed  Google Scholar 

  7. Bremerich J, Bilecen D, Reimer P (2007) MR angiography with blood pool contrast agents. Eur Radiol 17:3017–3024

    Article  PubMed  Google Scholar 

  8. Shamsi K, Yucel EK, Chamberlin P (2006) A summary of safety of gadofosveset (MS-325) at 0.03 mmol/kg body weight dose: phase II and phase III clinical trials data. Invest Radiol 41:822–830

    Article  CAS  PubMed  Google Scholar 

  9. Rigsby C, Popescu A, Boylan E et al (2014) Safety of a blood pool contrast agent in children and young adults. Pediatr Radiol 44:S81

    Article  Google Scholar 

  10. Prince MR, Pearson GD, Zhang HL et al (2010) Advantages of blood pooling in pediatric MR angiography. JACC Cardiovasc Imaging 3:514–516

    Article  PubMed  Google Scholar 

  11. Zou Z, Zhang HL, Roditi GH et al (2011) Nephrogenic systemic fibrosis: review of 370 biopsy-confirmed cases. JACC Cardiovasc Imaging 4:1206–1216

    Article  PubMed  Google Scholar 

  12. Sabach AS, Bruno M, Kim D et al (2013) Gadofosveset trisodium: abdominal and peripheral vascular applications. AJR Am J Roentgenol 200:1378–1386

    Article  PubMed  Google Scholar 

  13. Kim CY, Heye T, Bashir MR et al (2013) Gadofosveset-enhanced magnetic resonance angiography of the thoracic vasculature in the equilibrium phase: feasibility and impact of dose. J Comput Assist Tomogr 37:732–736

    Article  CAS  PubMed  Google Scholar 

  14. Goyen M, Edelman M, Perreault P et al (2005) MR angiography of aortoiliac occlusive disease: a phase III study of the safety and effectiveness of the blood-pool contrast agent MS-325. Radiology 236:825–833

    Article  PubMed  Google Scholar 

  15. Haneder S, Attenberger UI, Biffar A et al (2011) Gadofosveset: parameter optimization for steady-state imaging of the thoracic and abdominal vasculature. Invest Radiol 46:678–685

    PubMed  Google Scholar 

  16. Klessen C, Hein PA, Huppertz A et al (2007) First-pass whole-body magnetic resonance angiography (MRA) using the blood-pool contrast medium gadofosveset trisodium: comparison to gadopentetate dimeglumine. Invest Radiol 42:659–664

    Article  PubMed  Google Scholar 

  17. Maki JH, Wang M, Wilson GJ et al (2009) Highly accelerated first-pass contrast-enhanced magnetic resonance angiography of the peripheral vasculature: comparison of gadofosveset trisodium with gadopentetate dimeglumine contrast agents. J Magn Reson Imaging 30:1085–1092

    Article  PubMed  Google Scholar 

  18. Hadizadeh DR, Gieseke J, Lohmaier SH et al (2008) Peripheral MR angiography with blood pool contrast agent: prospective intraindividual comparative study of high-spatial-resolution steady-state MR angiography versus standard-resolution first-pass MR angiography and DSA. Radiology 249:701–711

    Article  PubMed  Google Scholar 

  19. Vasanawala SS, Chan FP, Newman B et al (2011) Combined respiratory and cardiac triggering improves blood pool contrast-enhanced pediatric cardiovascular MRI. Pediatr Radiol 41:1536–1544

    Article  PubMed Central  PubMed  Google Scholar 

  20. Naehle CP, Kaestner M, Muller A et al (2010) First-pass and steady-state MR angiography of thoracic vasculature in children and adolescents. JACC Cardiovasc Imaging 3:504–513

    Article  PubMed  Google Scholar 

  21. Boettcher J, Pfeil A, Wolf G et al (2013) Magnetic resonance venography of the upper venous system with blood pool contrast agent: comparison of two different T1-weighted sequences. Clin Imaging 37:245–250

    Article  PubMed  Google Scholar 

  22. Huang SY, Kim CY, Miller MJ et al (2013) Abdominopelvic and lower extremity deep venous thrombosis: evaluation with contrast-enhanced MR venography with a blood-pool agent. AJR Am J Roentgenol 201:208–214

    Article  PubMed  Google Scholar 

  23. Pfeil A, Betge S, Poehlmann G et al (2012) Magnetic resonance VIBE venography using the blood pool contrast agent gadofosveset trisodium — an interrater reliability study. Eur J Radiol 81:547–552

    Article  PubMed  Google Scholar 

  24. Ghanouni P, Walters SG, Vasanawala SS (2012) Rapid MR venography in children using a blood pool contrast agent and multi-station fat-water-separated volumetric imaging. Pediatr Radiol 42:242–248

    Article  PubMed Central  PubMed  Google Scholar 

  25. Stein PD, Chenevert TL, Fowler SE et al (2010) Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism: a multicenter prospective study (PIOPED III). Ann Intern Med 152:434–443

    Article  PubMed Central  PubMed  Google Scholar 

  26. Hansch A, Betge S, Poehlmann G et al (2011) Combined magnetic resonance imaging of deep venous thrombosis and pulmonary arteries after a single injection of a blood pool contrast agent. Eur Radiol 21:318–325

    Article  PubMed  Google Scholar 

  27. Pressacco J, Papas K (2012) Gadofosveset-enhanced magnetic resonance angiography as a means of evaluating pulmonary arteriovenous malformation: a case report. Magn Reson Imaging 30:886–888

    Article  PubMed  Google Scholar 

  28. Williams J, Vasanawala SS (2011) Active gastrointestinal hemorrhage identification by blood pool contrast-enhanced magnetic resonance angiography. Pediatr Radiol 41:1198–1200

    Article  PubMed  Google Scholar 

  29. Jacobi B, Schubert T, Partovi S et al (2012) Gadofosveset — a blood pool contrast agent used with MRI to detect obscure gastrointestinal bleeding: a case report. Am J Gastroenterol 107:1107–1109

    Article  PubMed  Google Scholar 

  30. Semionov A, Pressacco J (2011) Gadofosveset-enhanced 4D magnetic resonance angiography as a means of localizing the site of post aortic graft leak. Magn Reson Imaging 29:300–302

    Article  PubMed  Google Scholar 

  31. Milot L, Haider M, Foster L et al (2012) Gadofosveset trisodium in the investigation of focal liver lesions in noncirrhotic liver: early experience. J Magn Reson Imaging 36:738–742

    Article  PubMed  Google Scholar 

Download references

Conflicts of interest

None

Author information

Authors and Affiliations

  1. Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., St. Louis, MO, 63110, USA

    Shannon G. Farmakis & Geetika Khanna

  2. Department of Radiology, St. Louis University School of Medicine, St. Louis, MO, USA

    Shannon G. Farmakis

Authors
  1. Shannon G. Farmakis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Geetika Khanna
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Geetika Khanna.

Additional information

CME activity

This article has been selected as the CME activity for the current month. Please visit the SPR Web site at www.pedrad.org on the Education page and follow the instructions to complete this CME activity.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Farmakis, S.G., Khanna, G. Extracardiac applications of MR blood pool contrast agent in children. Pediatr Radiol 44, 1598–1609 (2014). https://doi.org/10.1007/s00247-014-3167-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00247-014-3167-x

Keywords

Search

Navigation