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Coincidence FDG-PET in the evaluation of Langerhans' cell histiocytosis: preliminary findings

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Abstract

Background

Bone involvement in Langerhans' cell histiocytosis (LCH) is common. Both bone scintigraphy and plain films are used to identify osseous lesions, but lack specificity for disease activity and response to therapy. FDG-PET is a sensitive technique for identifying bone lesions when histiocytes are present.

Objective

To describe the potential of coincidence FDG-PET (cFDG-PET) for identification of active bone lesions in LCH and to determine whether it can provide more specific information regarding lesional response to therapy than bone scintigraphy or radiography.

Materials and methods

The clinical data and imaging findings of three patients with osseous lesions of LCH were retrospectively reviewed.

Results

cFDG-PET identified all active LCH osseous lesions in these patients, differentiated active from healed lesions, and demonstrated normalization of uptake in a treated lesion earlier than bone scintigraphy and radiography.

Conclusion

cFDG-PET appears to have greater specificity than bone scintigraphy and radiography for the identification of active osseous lesions in LCH. It also may predict response to treatment earlier than conventional techniques. Its use in the evaluation of LCH warrants further study.

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Authors and Affiliations

  1. Department of Radiology, Columbus Children's Hospital, 700 Children's Way, Columbus, OH 43205, USA

    Larry A. Binkovitz & Brent H. Adler

  2. Department of Hematology and Oncology, Columbus Children's Hospital, 700 Children's Way, Columbus, OH 43205, USA

    Randal S. Olshefski

Authors
  1. Larry A. Binkovitz
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  2. Randal S. Olshefski
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  3. Brent H. Adler
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Corresponding author

Correspondence to Larry A. Binkovitz.

Additional information

Presented at the 2002 meeting of the Society for Pediatric Radiology, Philadelphia, Pennsylvania

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Binkovitz, L.A., Olshefski, R.S. & Adler, B.H. Coincidence FDG-PET in the evaluation of Langerhans' cell histiocytosis: preliminary findings. Pediatr Radiol 33, 598–602 (2003). https://doi.org/10.1007/s00247-003-0943-4

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  • DOI: https://doi.org/10.1007/s00247-003-0943-4

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