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Does smoking have any effect on urinary stone composition and the distribution of trace elements in urine and stones?

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Abstract

The role of particular elements in lithogenesis is still unclear and debated. Probably some of them may promote or conversely inhibit crystal nucleation of organic or mineral species. A few epidemiological data link smoking with the risk of calcium stones. The aim of this hospital-based study was to evaluate the distribution of trace elements in urine and urinary stones, and possible correlation with stone constituents in smoking and non-smoking individuals. 209 stones and urine samples collected from idiopathic stone-formers were analyzed to evaluate the mineral composition and the distribution of elements, 29 in stones and 21 in urine. Values were statistically compared considering smoking, arterial hypertension and coronary heart disease as grouping variables. No differences were noted either for comparison of mineral components or the elements concentrations in stones in both groups. The concentration of mercury in urine was higher in smokers than in non-smokers, but the statistical significance was at the moderate level. Our findings do not support the concept of possible association between smoking and urinary lithogenesis, but we believe that further investigations are needed in this area.

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Acknowledgments

This study has been granted from 2007 to 2010 scientific fund for research projects of Polish Ministry of Science and Higher Education (NN403/1098/33).

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Authors and Affiliations

  1. Department of Urology, Pomeranian Medical University, ul. Powstancow Wlkp. 72, 70-111, Szczecin, Poland

    Marcin Słojewski, Adam Gołąb & Andrzej Sikorski

  2. Laboratory of Drug Toxicology and Pharmacoeconomy, Pomeranian Medical University, ul. Zolnierska 48, 71-210, Szczecin, Poland

    Bogusław Czerny

  3. Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, ul. Powstancow Wlkp. 72, 70-111, Szczecin, Poland

    Krzysztof Safranow, Katarzyna Jakubowska, Maria Olszewska & Dariusz Chlubek

  4. Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, ul. Powstancow Wlkp. 72, 70-111, Szczecin, Poland

    Marek Droździk & Andrzej Pawlik

  5. Central Laboratory, Clinical Hospital Nr 2, ul. Powstancow Wlkp. 72, 70-111, Szczecin, Poland

    Elżbieta Byra

Authors
  1. Marcin Słojewski
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  2. Bogusław Czerny
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  3. Krzysztof Safranow
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  6. Katarzyna Jakubowska
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  7. Maria Olszewska
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  8. Adam Gołąb
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  9. Elżbieta Byra
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  10. Dariusz Chlubek
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  11. Andrzej Sikorski
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Corresponding author

Correspondence to Marcin Słojewski.

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Słojewski, M., Czerny, B., Safranow, K. et al. Does smoking have any effect on urinary stone composition and the distribution of trace elements in urine and stones?. Urol Res 37, 317–322 (2009). https://doi.org/10.1007/s00240-009-0221-5

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  • DOI: https://doi.org/10.1007/s00240-009-0221-5

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