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Heavy elements in urinary stones

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Abstract

The presence and role of heavy metals in urinary stones is debated. We investigated the distribution of trace heavy metals in 78 calculi of well-defined composition by means of microfluorescence X analysis using synchrotron radiation. Seven elements were identified, the most abundant being Zn and Sr which together accounted for 91% of the heavy metal content of stones. The other heavy metals were Fe, Cu, Rb, Pb and Se. Zn and Sr were virtually confined to calcium-containing stones, whereas only trace amounts were found in uric acid or cystine stones. Among calcium stones, Zn and Sr were more abundant in calcium phosphate than in calcium oxalate stones and, in the latter, in weddellite than in whewellite stones. Fe, Cu and Rb were much less abundant and also found mainly in calcium stones. Pb was significantly less abundant than in previous studies, thus suggesting a rarefaction of Pb in the environment, and appreciable amounts of Se were found only in cystine stones. In conclusion, the preponderance of Zn and Sr, both bivalent ions, in calcium-containing stones suggests a substitution process of calcium by metal ions with similar charge and radius rather than a contribution of the metals to stone formation. Further studies are needed to examine the relationships between urine concentration in calcium or other solutes and the amount of Zn and Sr in calcium stones.

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References

  1. Daudon M, Doré JC, Jungers P, Lacour B (2004) Changes in stone composition according to age and gender of patients: a multivariate epidemiological approach. Urol Res 32:241

    Article  PubMed  Google Scholar 

  2. Durak I, Kilic Z, Sahin A, Akpoyraz M (1992) Analysis of calcium, iron, copper and zinc contents of nucleus and crust parts of urinary calculi. Urol Res 20:23

    Article  PubMed  CAS  Google Scholar 

  3. Perk H, Ahmet Serel T, Kosar A, Deniz N, Sayin A (2002) Analysis of the trace element contents of inner nucleus and outer crust parts of urinary calculi. Urol Int 68:286

    Article  PubMed  CAS  Google Scholar 

  4. Oka T, Yoshioka T, Koide T, Takaha M, Sonoda T (1987) Role of magnesium in the growth of calcium oxalate monohydrate and calcium oxalate dihydrate crystals. Urol Int 42:89

    Article  PubMed  CAS  Google Scholar 

  5. Sutor DJ (1969) Growth studies of calcium oxalates in the presence of various ions and compounds. Br J Urol 41:171

    Article  PubMed  CAS  Google Scholar 

  6. Grases F, Genestar C, Mill A (1989) The influence of some metallic ions and their complexes on the kinetics of crystal growth of calcium oxalate. J Crystal Growth 94:507

    Article  CAS  Google Scholar 

  7. Meyer JL, Thomas WC Jr (1982) Trace metal-citric acid complexes as inhibitors of calcification and crystal growth. II. Effects of Fe(III), Cr(III) and Al(III) complexes on calcium oxalate crystal growth. J Urol 128:1376

    PubMed  CAS  Google Scholar 

  8. Hesse A, Dietze HJ, Berg W, Hienzsch E (1977) Mass spectrometric trace element analysis of calcium oxalate uroliths. Eur Urol 3:359

    PubMed  CAS  Google Scholar 

  9. Levinson AA, Nosal M, Davidman M, Prien EL Sr, Prien EL Jr, Stevenson RG (1978) Trace elements in kidney stones from three areas in the United States. Invest Urol 15:270

    PubMed  CAS  Google Scholar 

  10. Wandt MAE, Pougnet MAB (1986) Simultaneous determination of major and trace elements in urinary calculi by microwave-assisted digestion and inductively coupled plasma atomic emission spectrometric analysis. Analyst 111:1249

    Article  PubMed  CAS  Google Scholar 

  11. Joost J, Tessadri R (1987) Trace element investigations in kidney stone patients. Eur Urol 13:264

    PubMed  CAS  Google Scholar 

  12. Durak I, Kilic Z, Perk H, Sahin A, Yurtarslani, Yasar A, Küpeli S, Akpoyraz M (1990) Iron, copper, cadmium, zinc and magnesium contents of urinary tract stones and hair from men with stone disease. Eur Urol 17:243

    PubMed  CAS  Google Scholar 

  13. Hofbauer J, Steffan I, Höbarth K, Vujicic G, Schwetz H, Reich G, Zechner O (1991) Trace elements and urinary stone formation: new aspects of the pathological mechanism of urinary stone formation. J Urol 145:93

    PubMed  CAS  Google Scholar 

  14. Daudon M, Bader CA, Jungers P (1993) Urinary Calculi: Review of classification methods and correlations with etiology. Scanning microsc 7:1081

    PubMed  CAS  Google Scholar 

  15. Estepa L, Daudon M (1997) Contribution of Fourier transform infrared Spectroscopy to the identification of urinary stones and kidney crystal deposits. Biospectroscopy 3:347

    Article  CAS  Google Scholar 

  16. Chevallier P, Dhez P, Erko A, Firsov A, Legrand F, Populus P (1996) X-ray microprobes NIM B 113:122

    Article  CAS  Google Scholar 

  17. Khattech I, Jemal M (1997) A complete solid-solution exists between Ca and Sr in synthetic apatite. Thermochim Acta 298:23

    Article  CAS  Google Scholar 

  18. Arey JS, Seaman JC, Bertsch PM (1999) Immobilization of uranium in contaminated sediments by hydroxyapatite addition. Environ Sci Technol 33:337

    Article  CAS  Google Scholar 

  19. Marchat D, Bernache-Assollant D, Champion E (2007) Cadmium fixation by synthetic hydroxyapatite in aqueous solution,Thermal behaviour. J Hazard Mater 139:453

    Article  PubMed  CAS  Google Scholar 

  20. Miyaji F, Kono Y, Suyama Y (2005) Formation and structure of zinc-substituted calcium hydroxyapatite. Mater Res Bull 40:209

    Article  CAS  Google Scholar 

  21. Zhu K, Yanagisawa K, Shimanouchi R, Onda A, Kajiyoshi K (2006) Preferential occupancy of metal ions in the hydroxyapatite solid solutions synthetized by hydrothermal method. J Eur Ceramic Soc 26:509

    Article  CAS  Google Scholar 

  22. Eichert D, Sfihi H, Combes C, Rey C (2004) Specific characteristics of wet nanocrystalline apatites. Consequences on biomaterials and bone tissue. Key Eng Mater 927:254–256

    Google Scholar 

  23. Eichert D, Salomé M, Banu M, Susini J, Rey C (2005) Preliminary characterization of calcium chemical environment in apatite and non-apatite calcium phosphates of biological interest by X-ray absorption spectroscopy. Spectrochimica Acta B 60:850

    Article  CAS  Google Scholar 

  24. Giammar DE, Maus CJ, Xie L (2007) Effects of particle size and crystalline phase on lead adsorption to titanium dioxide nanoparticles. Environ Eng Sci 24:85

    Article  CAS  Google Scholar 

  25. Maurice-Estepa L, Levillain P, Lacour B, Daudon M (1999) Crystalline phase differentiation in urinary calcium phosphate and magnesium phosphate calculi. Scand J Urol Nephrol 33:299

    Article  PubMed  CAS  Google Scholar 

  26. Daudon M, Jungers P (2004) Clinical value of crystalluria and quantitative morphoconstitutional analysis of urinary calculi. Nephron Physiol 98:31

    Article  CAS  Google Scholar 

  27. Vezzoli G, Caumo A, Baragetti I, Zerbi S, Bellinzoni P, Centemero A, Rubinacci A, Moro G, Adamo D, Bianchi G, Soldati L (1999) Study of calcium metabolism in idiopathic hypercalciuria by strontium oral load test. Clin Chem 45:257

    PubMed  CAS  Google Scholar 

  28. Vezzoli G, Rubinacci A, Bianchini C, Arcidiacono T, Giambona S, Mignogna G, Fochesato E, Terranegra A, Cusi D, Soldati L (2003) Intestinal calcium absorption is associated with bone mass in stone-forming women with idiopathic hypercalciuria. Am J Kidney Dis 42:1177

    Article  PubMed  Google Scholar 

  29. Daudon M, Jungers P, Lacour B (2004) Intérêt clinique de l’étude de la cristallurie. Ann Biol Clin 62:379

    CAS  Google Scholar 

  30. Komaromy-Hiller G, Owen Ash K, Costa R, Howerton K (2000) Comparison of representative ranges based on U.S. patient population and literature reference intervals for urinary trace elements. Clin Chim Acta 296:71

    Article  PubMed  CAS  Google Scholar 

  31. Munoz JA, Valiente M (2005) Effects of trace metals on the inhibition of calcium oxalate crystallization. Urol Res 33:267

    Article  PubMed  CAS  Google Scholar 

  32. Michalke B (2004) Selenium speciation in human serum of cystic fibrosis patients compared to serum from healthy persons. J Chromatogr A 1058:203

    Article  PubMed  CAS  Google Scholar 

  33. Huel G, Frery N, Takser L, Jouan M, Hellier G, Sahuquillo J, Giordanella JP (2002) Evolution of blood lead levels in urban French population (1979–1995). Rev Epidemiol Sante Publique 50:287

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratoire de Physique des Solides, Bat 510, Université Paris Sud, 91405, Orsay, France

    D. Bazin

  2. LURE (Laboratoire d’Utilisation des Rayonnements Electroniques), Université Paris-Sud, 91405, Orsay, France

    P. Chevallier

  3. CRMHT-CNRS 1D avenue de la Recherche Scientifique, 45071, Orléans Cedex 2, France

    G. Matzen

  4. Laboratoire de Biochimie A, AP-HP, Hôpital Necker, 149, Rue de Sèvres, 75743, Paris Cedex 15, France

    P. Jungers & M. Daudon

Authors
  1. D. Bazin
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  2. P. Chevallier
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  3. G. Matzen
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  4. P. Jungers
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  5. M. Daudon
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Correspondence to M. Daudon.

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Bazin, D., Chevallier, P., Matzen, G. et al. Heavy elements in urinary stones. Urol Res 35, 179–184 (2007). https://doi.org/10.1007/s00240-007-0099-z

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  • DOI: https://doi.org/10.1007/s00240-007-0099-z

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