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Identifying radiographic specificity for phosphatase and tensin homolog and epidermal growth factor receptor changes: a quantitative analysis of glioblastomas

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Abstract

Introduction

Phosphatase and tensin homolog (PTEN) loss and epidermal growth factor receptor (EGFR) amplification are common genetic alterations in malignant gliomas. This study aimed to investigate the anatomical relationship of tumor-related PTEN and EGFR expression in 140 patients with histologically confirmed de novo glioblastoma.

Methods

Preoperative magnetic resonance images were retrospectively analyzed. The lesions of each patient were segmented manually and registered to a standard brain space. Overlaying of the lesions was performed, and specific brain regions associated with PTEN loss and EGFR amplification were identified by voxel-based lesion-symptom mapping analyses.

Results

A cluster located in the right frontal lobe was found to be associated with high occurrence of PTEN loss, whereas a cluster in the right parietal lobe was demonstrated to be specifically associated with high occurrence of EGFR amplification. An overlap of the two clusters was observed at the posterior portion of the right parietal lobe.

Conclusions

Based on voxel-based imaging analyses, our results suggest that genetic changes during the tumorigenic process may have anatomical specificity. We hope that this identified correlation between these biomarkers and the anatomical distribution of glioblastomas will help enhance our understanding of the molecular mechanisms underlying glioblastoma development and progression.

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Ethical standards and patient consent

We declare that all human and animal studies have been approved by the Ethics Committee of Beijing Tiantan Hospital and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that all patients gave informed consent prior to inclusion in this study.

Acknowledgments

We would like to thank Yuling Yang for tissue sample collection and clinical data retrieval. This work was supported by funding from the National 973 Program (No.2011CB707804), the National High Technology Research and Development Program (No.2012AA02A508), the National Basic Research Program of China (No.2015CB755500) and the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (No.2013BAI09B03).

Conflict of interest

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Beijing Neurosurgical Institute, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China

    Yinyan Wang, Tan Zhang & Tao Jiang

  2. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Yinyan Wang, Xing Fan, Chuanbao Zhang & Lei Wang

  3. Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China

    Xiaoxia Peng

  4. Siemens Healthcare, MR Collaboration NE Asia, Beijing, China

    Tianyi Qian

  5. Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Jun Ma & Shaowu Li

  6. China National Clinical Research Center for Neurological Diseases, Beijing, China

    Lei Wang

  7. Beijing Institute for Brain Disorders Brain Tumor Center, Beijing, China

    Tao Jiang

  8. Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China

    Jun Ma

Authors
  1. Yinyan Wang
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  7. Jun Ma
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  8. Lei Wang
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  9. Shaowu Li
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  10. Tao Jiang
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Corresponding authors

Correspondence to Jun Ma or Tao Jiang.

Additional information

Yinyan Wang and Xing Fan contributed equally to this study.

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Wang, Y., Fan, X., Zhang, C. et al. Identifying radiographic specificity for phosphatase and tensin homolog and epidermal growth factor receptor changes: a quantitative analysis of glioblastomas. Neuroradiology 56, 1113–1120 (2014). https://doi.org/10.1007/s00234-014-1427-y

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  • DOI: https://doi.org/10.1007/s00234-014-1427-y

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